The organization and evolution of the immunogenetic systems in the American mink

Baranov, O. K.

doi:10.1111/j.1439-0388.1988.tb00278.x

Cited by 4 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Before interpreting the results, it should be recalled that the identification of mink Lpm‐system was based on two immunogenetic characteristics: polymorphism for the corresponding locus and high immunogenicity of the allotypic variants of Lpm‐macroglobulins controlled by allelic and closely linked genes of the Lpm‐family (B aranov 1976, 1988; B aranov et al 1976, 1978). We suggested that the homologues of Lpm in other species in which the corresponding protein is identified (S humny et al 1989) would possess, at least, similar features, i. e. the corresponding locus would be sufficiently polymorphic, and the proteins controlled by the allelic genes would be strongly alloantigenic.…”

Section: Discussionmentioning

confidence: 99%

“…This communication presents further information concerning the evolution of the Lpm system in American mink. For relevant preceding information the reader is referred to B aranov (1988). To recapitulate, the multigenic Lpm‐locus of mink controls allotypic polymorphism of Lpm‐macroglobulin (another nomenclature designated it as α 1 M), and it consists of a variety of closely linked genes with allelic variants.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A comparative study of the homologous Lpm‐system allotypes of alpha‐macroglobulins in American mink and Gp‐system allotypes of alpha‐macroglobulin in domestic pig

Yermolaev

Mirtskhoulava

Savina

et al. 1992

J Animal Breeding Genetics

Self Cite

View full text Add to dashboard Cite

Summary This paper summarizes our results with allotyping of alpha‐macroglobulins in pig and the comparative results with their homologs in mink. In p.g, 5 allotypes of α‐macroglobulins, αM1, αM2, αM3AB, αM4, and αM5ab were identified. It was found that αM1, a marker of α‐macroglobulin in pig, is homologous to human α2‐macroglobulin and mink α2‐macroglobulin; αM2‐αM5, the markers of the second isotypic variant of α‐macroglobulin in pig, are homologous to mink Lpm‐macroglobulin (α1M). The results of the International comparison test (ISABR, 1987–1988) have demonstrated αM1 is new and αM2‐αM5 correspond to the four allotypes of the Gp‐system in pig (Janik et al. 1983). It is concluded that the pig Gp and mink Lpm systems are homologous. Because the studied allotypes belong to α‐macroglobulins, their controlling locus is designated as the AM‐locus. The same designation is suggested for the homologous mink locus (instead of the previous Lpm). The genetic control of 5 allotypes of pig is analysed. The structure of the pig AM‐locus is described in detail, and its organization is compared with the mink homologous locus. Zusammenfassung Vergleichende Untersuchung von α‐Makroglobulin Allotypen des Lpm Systems beim Nerz und des Gp‐Systems beim Hausschwein Diese Veröffentlichung faßt unsere Ergebnisse bezüglich der Allotypen von α‐Makroglobulin des Schweines und die vergleichenden Ergebnisse ihrer Homologe beim Nerz zusammen. Beim Schwein wurden 5 Allotypen des α‐Makroglobulins (αM1, αM2, αM3, αM4 und αM5) identifiziert. Das αM1, ein Marker des α‐Makroglobulins des Schweines, ist homolog zu dem menschlichen α2‐Makroglobulin und dem α2‐Makroglobulin des Nerzes; αM2−αM5, Marker der zweiten isotopischen Variante des α‐Makroglobulin, sind dem Nerz Lpm‐Macroglobulin (α1M) homolog. Die Ergebnisse des Internationalen Vergleichstestes (ISABR, 1987–1988) hatten demonstriert, daß αM1 neu ist, und daß αM2−αM5 mit den vier Allotypen des Gp‐Systems vergleichbar sind (Janik et al. 1983). Es wird daraus geschlossen, daß Schweine Gp und Nerz Lpm‐System homolog ist. Da die untersuchten Allotypen dem α‐Makroglobulin angehören, wird ihr kontrollierender Locus AM‐Locus genannt. Die gleiche Benennung (statt der vorigen Lpm) wird für den homologen Nerz Locus vorgeschlagen. Die genetische Steuerung der 5 Allotypen des Schweines sind damit auch analysiert, die Struktur des Schweine AM‐Locus beschrieben, und seine Organisation ist mit der homologen des Nerz‐Locus verglichen.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comparative study of the homologous Lpm‐system allotypes of alpha‐macroglobulins in American mink and Gp‐system allotypes of alpha‐macroglobulin in domestic pig

Yermolaev

Mirtskhoulava

Savina

et al. 1992

J Animal Breeding Genetics

Self Cite

View full text Add to dashboard Cite

show abstract

Localization of the ?2-macroglobulin gene and Lpm gene family on mink chromosome 9

Yermolaev

Karasik

Khlebodarova

et al. 1989

Theoret. Appl. Genetics

View full text Add to dashboard Cite

Using cloned cDNA for human α2-macroglobulin (A2M) as a probe, mink-Chinese hamster hybrid cells were analysed. The results allowed us to assign a gene for A2M to mink chromosome 9. Breeding tests demonstrated that the Lpm-locus coding for other related α-macroglobulin protein and the gene for peptidase B (PEPB) are linked 11±3 cm apart. The PEPB gene is located on mink chromosome 9, and hence, the Lpw-locus is on the same mink chromosome. The relationship of the genetic systems controlling the isotypically different α-macroglobulins in mink serum are discussed.

show abstract

Three twinning types in mink (Mustela vison) embryogenesis

Isakova

2007

Russ J Genet

View full text Add to dashboard Cite

The organization and evolution of the immunogenetic systems in the American mink

Cited by 4 publications

References 29 publications

A comparative study of the homologous Lpm‐system allotypes of alpha‐macroglobulins in American mink and Gp‐system allotypes of alpha‐macroglobulin in domestic pig

A comparative study of the homologous Lpm‐system allotypes of alpha‐macroglobulins in American mink and Gp‐system allotypes of alpha‐macroglobulin in domestic pig

Localization of the ?2-macroglobulin gene and Lpm gene family on mink chromosome 9

Three twinning types in mink (Mustela vison) embryogenesis

Contact Info

Product

Resources

About