The origins and formation of bone-resorbing osteoclasts

Elson, Ari; Anuj, Anuj; Barnea-Zohar, Maayan; Reuven, Nina

doi:10.1016/j.bone.2022.116538

Cited by 41 publications

(28 citation statements)

References 201 publications

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“…In addition, a free ligand could bind to another free ligand, e.g., OPG can bind to RANKL. These pathways have been shown to be the main regulators of cell differentiation and proliferation (Krishnan et al 2006; Boyce and Xing 2008; Lin et al 2009; Tang et al 2009; Warren et al 2015; Elson et al 2022). The osteocytes were considered the main mechanosensors of the mechanical signal (Santos et al 2009; Klein-Nulend et al 2012, 2013) and they promoted bone formation or resorption by releasing cytokines into the volume to regulate the signaling pathways affecting eventually the osteoblasts and osteoclasts.…”

Section: Introductionmentioning

confidence: 99%

Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-basedin silicomodel using single-cell mechanomics

Boaretti

Marques

Ledoux

et al. 2022

Preprint

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Bone remodeling is regulated by the interaction between different cells and tissues across many spatial and temporal scales. In silico models have been of help to further understand the signaling pathways that regulate the spatial cellular interplay. We have established a 3D multiscale micro-multiphysics agent-based (micro-MPA)in silicomodel of trabecular bone remodeling using longitudinalin vivodata from the sixth caudal vertebra (CV6) of PolgA(D257A/D257A)mice, a mouse model of premature aging. Our model includes a variety of cells as single agents and receptor-ligand kinetics, mechanotransduction, diffusion and decay of cytokines which regulate the cells' behavior. The micro-MPA model was applied for simulating trabecular bone remodeling in the CV6 of 5 mice over 4 weeks and we evaluated the static and dynamic morphometry of the trabecular bone microarchitecture. We identified a configuration of the model parameters to simulate a homeostatic trabecular bone remodeling. Additionally, our simulations showed different anabolic, anti-anabolic, catabolic and anticatabolic responses with an increase or decrease by one standard deviation in the levels of osteoprotegerin (OPG), receptor activator of nuclear factor kB ligand (RANKL), and sclerostin (Scl) produced by the osteocytes. From these results, we concluded that OPG inhibits osteoclastic bone resorption by reducing the osteoclast recruitment, RANKL promotes bone resorption by enhancing the osteoclast recruitment and Scl blocks bone formation by inhibiting osteoblast differentiation. The variations in trabecular bone volume fraction and thickness (BV/TV and Tb.Th) were relatively higher with variations of one standard deviation in the levels of RANKL compared to OPG and Scl. This micro-MPA model will help us to better understand how cells respond to the mechanical signal by changing their activity in response to their local mechanical environment.

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Section: Introductionmentioning

confidence: 99%

Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-basedin silicomodel using single-cell mechanomics

Boaretti

Marques

Ledoux

et al. 2022

Preprint

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“…They can adhere to bone and secrete protons and enzymes to degrade the bone matrix. 23 For osteoclasts, there are also many specific markers, mainly various enzymes. Tartrate-resistant acid phosphatase (TRAP) is a specific enzyme of osteoclasts, and TRAP staining is commonly used in histology to identify osteoclasts.…”

Section: Balancing the Effects Of Osteoblasts And Osteoclastsmentioning

confidence: 99%

Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

Luo,

Liu,

Zhang

et al. 2023

Biomater. Sci.

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“…For instance, OBs represent one of the main sources of MFs colony-stimulating factor (M-CSF), which is very important for OCs differentiation [ 78 , 87 , 88 , 89 ], highlighting the importance of MFs-OBs-OCs interrelations. MFs and other innate immune system cells are OCs precursors [ 90 ] and also play important roles in mediating osteoclast-genesis. M1 MFs induces osteoclast-genesis by releasing cytokines such as: IL-1a/b [ 91 , 92 ], IL-6 [ 93 , 94 ], and TNF-a [ 95 , 96 ].…”

Section: Autophagy In the Main Cellular Types Involved In Dental Impl...mentioning

confidence: 99%

Autophagy Plays Multiple Roles in the Soft-Tissue Healing and Osseointegration in Dental Implant Surgery—A Narrative Review

et al. 2022

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Dental endo-osseous implants have become a widely used treatment for replacing missing teeth. Dental implants are placed into a surgically created osteotomy in alveolar bone, the healing of the soft tissue lesion and the osseointegration of the implant being key elements to long-term success. Autophagy is considered the major intracellular degradation system, playing important roles in various cellular processes involved in dental implant integration. The aim of this review is an exploration of autophagy roles in the main cell types involved in the healing and remodeling of soft tissue lesions and implant osseointegration, post-implant surgery. We have focused on the autophagy pathway in macrophages, endothelial cells; osteoclasts, osteoblasts; fibroblasts, myofibroblasts and keratinocytes. In macrophages, autophagy modulates innate and adaptive immune responses playing a key role in osteo-immunity. Autophagy induction in endothelial cells promotes apoptosis resistance, cell survival, and protection against oxidative stress damage. The autophagic machinery is also involved in transporting stromal vesicles containing mineralization-related factors to the extracellular matrix and regulating osteoblasts’ functions. Alveolar bone remodeling is achieved by immune cells differentiation into osteoclasts; autophagy plays an important and active role in this process. Autophagy downregulation in fibroblasts induces apoptosis, leading to better wound healing by improving excessive deposition of extracellular matrix and inhibiting fibrosis progression. Autophagy seems to be a dual actor on the scene of dental implant surgery, imposing further research in order to completely reveal its positive features which may be essential for clinical efficacy.

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The origins and formation of bone-resorbing osteoclasts

Cited by 41 publications

References 201 publications

Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-basedin silicomodel using single-cell mechanomics

Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-basedin silicomodel using single-cell mechanomics

Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

Autophagy Plays Multiple Roles in the Soft-Tissue Healing and Osseointegration in Dental Implant Surgery—A Narrative Review

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