The orthograde labeling of postganglionic sympathetic cardiac nerves in the dog and cat as demonstrated by autoradiography

Foody, Lawrence T.; Niehoff, Michael L.; D'Agrosa, Louis S.; Connors, Natalie A.; Sullivan, James M.

doi:10.1016/0165-1838(79)90007-9

Cited by 7 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dorsal mediastinal nerves course caudally to project onto the hem, accompanying the right and left coronary vessels as the right and left coronary nerves. The Beft lateral cardiac nerve projects directly onto the left lateral surface of the heart ( h o u r and Randall 1975;Foody et al 1979), not accompanying any major vessel. The rnediastinal nerves produced, when stimulated, combinations sf bradycardia or tachycardia, positive or negative atrial inotropisrn, as well as augmentation in right and (or) Ieft ventricular IMP and IVB (Fig.…”

Section: Discussionmentioning

confidence: 99%

Functional anatomy of the canine mediastinal cardiac nerves located at the base of the heart

Brandys¹,

Randall²,

Armour³

1986

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

The major canine cardiopulmonary nerves which arise from the middle cervical and stellate ganglia and the vagi course toward the heart in the dorsal mediastinum where they form, at the base of the heart dorsal to the pulmonary artery and aorta, the dorsal mediastinal cardiac nerves. In addition, the left caudal pole and interganglionic nerves project onto the left lateral side of the heart as the left lateral cardiac nerve. These nerves contain afferent and (or) efferent axons which, upon stimulation, modify specific cardiac regions and (or) systemic pressure. In addition, with the exception of the left lateral cardiac nerve, stimulation of each of these nerves produces compound action potentials in the cranial ends of the majority of the major cardiopulmonary nerves demonstrating that axons in each dorsal mediastinal cardiac nerve interconnect with axons in the majority of the cardiopulmonary nerves. Axons in the left lateral cardiac nerve connect primarily with axons in the left caudal pole and left interganglionic nerves. The dorsal mediastinal nerves project distally onto the heart as coronary nerves accompanying the right or left coronary arteries. These innervated the ventricular myocardium which is supplied by their respective vessels. The left lateral cardiac nerve projects directly onto the lateral epicardium of the left ventricle. The dorsal mediastinal and left lateral cardiac nerves are the major sympathetic cardiac nerves. Thus, the cardiac nerves located in the mediastinum at the base of the heart are not simple extensions of cardiopulmonary nerves, but rather have a unique anatomy and function of their own.

show abstract

Section: Discussionmentioning

confidence: 99%

Functional anatomy of the canine mediastinal cardiac nerves located at the base of the heart

Brandys¹,

Randall²,

Armour³

1986

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Although the autoradiography identifica tion of orthogradely labelled neurons has been used extensively to study central nerv ous system pathways [4,6], autoradio graphic procedures have only recently been employed to investigate the innervation of the heart [8,9,21] and other components of the autonomic nervous system [14,28]. Autoradiographic techniques allow the investigation and accurate interpretation of the origin, course, and distribution of nerve fibers.…”

Section: Introductionmentioning

confidence: 99%

An Orthograde Labelling Study of Axons of the Dorsal Motor Nucleus of the Vagus to Rat Cardiac Ganglia as Demonstrated by Autoradiography

Sullivan¹,

Connors²

1981

Cells Tissues Organs

Self Cite

View full text Add to dashboard Cite

Central organization of the cardiac vagus has not been clarified. Retrograde changes produced in medulla oblongata neurons after section of vagal branches has favored the dorsal motor nucleus of the vagus (DMNX). Current information concerning the origin, course, and termination of vagal preganglionic fibers within cardiac ganglia is conflicting. The explicit purpose of this study was to determine if vagal fibers originated specifically within the DMNX proper. Fibers within the cardiac ganglia were labelled with ³ H-leucine following injection into the DMNX. 12 adult albino rats were studied. DMNX were injected with 25 µCi ³H-leucine reconstituted to 5 µl. Animals were sacrificed by transcardial perfusion following a 4-day survival period. Serial cross-sections of the caudal pons, medulla oblongata, and thoracic viscera were processed for autoradiography. DMNX possessed a heavy incorporation of the radiochemical. Label was observed within the axons of the vagi. Cardiac ganglia contained labelled vagal fibers in close proximity to the postganglionic somata. Cardiac ganglia containing labelled preganglionic vagal axons were located in the cardiac plexuses and in the epicardium. Results show a labelled vagal preganglionic input to cardiac ganglia from the DMNX.

show abstract

Localization of sympathetic postganglionic neurons of physiologically identified cardiac nerves in the dog

Armour

Hopkins

1981

J of Comparative Neurology

View full text Add to dashboard Cite

Cardiac nerves were identified physiologically and injected with horseradish peroxidase in 38 dogs. Retrogradely labeled neurons were present in the greatest number in the middle cervical ganglion, whereas fewer labeled neurons were present in the stellate ganglion. Only occasional neurons in the superior cervical ganglion were labeled, and no labelphysiologically and injected with horseradish peroxidase in 38 dogs. Retrogradely labeled neurons were present in the greatest number in the middle cervical ganglion, whereas fewer labeled neurons were present in the stellate ganglion. Only occasional neurons in the superior cervical ganglion were labeled, and no labelphysiologically and injected with horseradish peroxidase in 38 dogs. Retrogradely labeled neurons were present in the greatest number in the middle cervical ganglion, whereas fewer labeled neurons were present in the stellate ganglion. Only occasional neurons in the superior cervical ganglion were labeled, and no labeled cells were found in the T3 to T6 paravertebral ganglia or in the ganglia contralateral to the nerve injected. following injections into specific cardiac nerves, retrograde labeling was widespread within the middle cervical ganglion, and the distributions of labeled neurons from different nerves overlapped considerably. In the middle cervical ganglion there was little or no regional grouping of cells projecting to specific cardiac nerves. within the stellate ganglion, however, te cardiac-sympathetic cells were clustered primarily at the cranial pole near toe origin of the ventral and dorsal ansae. Mediastinal ganglia and ganglia located in cardiac nerves were frequently as heavily labeled as the ipsilateral stellate ganglion. The occurrence of heavy labeling in mediastinal and cardiac nerve ganglia indicates that these hitherto unreported ganglia play a significant role in cardiac neural regulation. These data imply that the organization of sympathetic neurons controlling the heart is much more complex than has previously been considered.

show abstract

The orthograde labeling of postganglionic sympathetic cardiac nerves in the dog and cat as demonstrated by autoradiography

Cited by 7 publications

References 19 publications

Functional anatomy of the canine mediastinal cardiac nerves located at the base of the heart

Functional anatomy of the canine mediastinal cardiac nerves located at the base of the heart

An Orthograde Labelling Study of Axons of the Dorsal Motor Nucleus of the Vagus to Rat Cardiac Ganglia as Demonstrated by Autoradiography

Localization of sympathetic postganglionic neurons of physiologically identified cardiac nerves in the dog

Contact Info

Product

Resources

About