The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

Tewarie, Prejaas; Balk, Lisanne J.; Costello, Fiona; Green, Ari; Martin, Roland; Schippling, Sven; Petzold, Axel

doi:10.1371/journal.pone.0034823

Cited by 464 publications

(435 citation statements)

References 16 publications

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“…Room light conditions were dimmed and no pharmacological pupil dilation was used. Retinal thickness data were obtained by means of quality controlled automated segmentation of the optic disc (12°ring scan) and macula (20 × 20°, 25 B‐scan composite volume, using the mean thickness of the 1, 3, 6 mm grid) 18, 19. Segmentation of the IRLs consisted of the cumulative thickness from the inner limiting membrane to the outer border of the inner plexiform layer.…”

Section: Methodsmentioning

confidence: 99%

Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study

Tewarie

Balk

Hillebrand

et al. 2017

Ann Clin Transl Neurol

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BackgroundWe conducted a multi‐modal optical coherence tomography (OCT) and magnetoencephalography (MEG) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity (FC) in the visual network influenced by optic neuritis (ON) in patients with multiple sclerosis (MS).MethodsOne hundred and two MS patients were included in this MEG/OCT study. Retinal OCT data were collected from the optic discs, macular region, and segmented. Neuronal activity and FC in the visual cortex was estimated from source‐reconstructed resting‐state MEG data by computing relative power and the phase lag index (PLI). Generalized estimating equations (GEE) were used to account for intereye within‐patient dependencies.ResultsThere was a significant relationship for both relative power and FC in the visual cortex with retinal layer thicknesses. The findings were influenced by the presence of MSON, particularly for connectivity in the alpha bands and the outer macular layers. In the absence of MSON, this relationship was dominated by the lower frequency bands (theta, delta) and inner and outer retinal layers.ConclusionThese results suggest that visual cortex FC more than activity alters in the presence of MSON, which may guide the understanding of FC plasticity effects following MSON.

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Section: Methodsmentioning

confidence: 99%

Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study

Tewarie

Balk

Hillebrand

et al. 2017

Ann Clin Transl Neurol

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“…An independent rater evaluated the quality of the OCT scans according to the OSCAR‐IB Consensus Criteria for Retinal OCT Quality Assessment (Tewarie et al., 2012). Scans with poor quality were excluded from subsequent analysis as well as OCT examinations with incomplete or incorrect scan protocol.…”

Section: Methodsmentioning

confidence: 99%

Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS

et al. 2016

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BackgroundNeurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated.ObjectiveTo investigate the association between focal cortical volume and thickness of retinal layers.MethodsFifty‐four patients (relapsing–remitting MS, mean age 40.5 years, mean disease duration 7.6 years, median EDSS 2) underwent OCT and MRI. The association between focal cortical volume and OCT measurements was investigated with voxel‐based morphometry (VBM). Patterns of association were determined with Yeo's functional network atlas and the Harvard‐Oxford cortical atlas. We used GEE models with cortical volumes from the FreeSurfer parcellation to confirm VBM results. Post hoc, we analyzed the association between OCT, focal cortical volumes, and an extended neuropsychological assessment in a subgroup of 14 patients.ResultsMacular retinal nerve fiber layer (mRNFL) and ganglion cell /inner plexiform layer (GCIPL) showed a robust association with mainly the insular cortex and the cingulate cortex. VBM findings were confirmed with FreeSurfer volumes. The post hoc analysis detected significant correlations between both OCT outcomes and cognition.ConclusionBesides the primary visual system, OCT outcomes show a correlation pattern with cortical regions that are known to be important for cognitive performance, predominantly the insula in both hemispheres. Thus, OCT should be further investigated as a marker for neurodegeneration in MS.

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“…11 Pharmacological dilatation was performed in all subjects to ensure optimal image quality and to permit careful retinal segmentation. The photographers rejected scans with motion artifacts (discontinuous jump).…”

Section: Examinationmentioning

confidence: 99%

Anatomical and functional retinal changes in multiple sclerosis

Cennamo

Romano

Vecchio

et al. 2015

Eye

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Aims The aims of this study was to report anatomical changes of the ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) thickness, and macular volume in patients with multiple sclerosis (MS). We also investigated the correlation between anatomical and functional changes in terms of visual acuity and macular sensitivity investigated and visual fields. Methods Prospective comparative study included 105 eyes of 53 consecutive patients. The patients were divided into two groups: group A included 56 eyes of 28 patients with diagnosis of MS; group B involved 49 eyes of 25 healthy patients. The examination included Goldmann tonometry, biomicroscopic and fundus oculi examination, retinography, GCC examination, circumpapillary RNFL (cpRNFL), and macular volume. The functional test included measurement of best-corrected visual acuity (BCVA), visual field, and MP. Results MS group showed a significant reduced GCC, cpRNFL, macular volume, BCVA, visual field, and macular sensitivity compared with the control group (Po0.001). This reduction was more representative (Po0.001) in patients with MS complicated by optic neuritis (ON). We found in the MS group a strong correlation between GCC thickness and macular volume (r 2 = 0.59, Po0.001) and also between GCC and RNFL thickness (r 2 = 0.48, Po0.001). There was also a correlation between macular sensitivity and macular volume reduction (r 2 = 0.25, Po0.001) and also between RNFL and macular volume (r 2 = 0.43, Po0.001). Conclusions The significant statistical evidence and the strong correlation between anatomical and functional parameters support the use of OCT and MP in the evaluation, treatment, and follow-up of patients diagnosed with MS.

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The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

Cited by 464 publications

References 16 publications

Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study

Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study

Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing–remitting MS

Anatomical and functional retinal changes in multiple sclerosis

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