The osmotic pressure of concentrated protein solutions: Effect of concentration and ph in saline solutions of bovine serum albumin

Vilker, Vincent L.; Colton, Clark K.; Smith, Kenneth A.

doi:10.1016/0021-9797(81)90106-5

Cited by 347 publications

(316 citation statements)

References 41 publications

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“…Serum albumins are the most abundant proteins present in the circulatory system of various organisms [109]. They play as a major role in maintaining osmotic blood pressure, drug disposition and efficacy [110].…”

Section: Serum Albumin Coatingmentioning

confidence: 99%

Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications

Agarwal

Curtin²,

Duffy

et al. 2016

Materials Science and Engineering: C

777

363

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Magnesium (Mg) and its alloys have been extensively explored as potential biodegradable implant materials for orthopaedic applications (e.g. Fracture fixation). However, the rapid corrosion of Mg based alloys in physiological conditions has delayed their introduction for therapeutic applications to date. The present review focuses on corrosion, biocompatibility and surface modifications of biodegradable Mg alloys for orthopaedic applications. Initially, the corrosion behaviour of Mg alloys and the effect of alloying elements on corrosion and biocompatibility is discussed. Furthermore, the influence of polymeric deposit coatings, namely sol-gel, synthetic aliphatic polyesters and natural polymers on corrosion and biological performance of Mg and its alloy for orthopaedic applications are presented. It was found that inclusion of alloying elements such as Al, Mn, Ca, Zn and rare earth elements provides improved corrosion resistance to Mg alloys. It has been also observed that sol-gel and synthetic aliphatic polyesters based coatings exhibit improved corrosion resistance as compared to natural polymers, which has higher biocompatibility due to their biomimetic nature. It is concluded that, surface modification is a promising approach to improve the performance of Mg-based biomaterials for orthopaedic applications.

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Section: Serum Albumin Coatingmentioning

confidence: 99%

Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications

Agarwal

Curtin²,

Duffy

et al. 2016

Materials Science and Engineering: C

777

363

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“…We now take advantage of the spherical symmetry of the system to eliminate the angular dependence of the equations, that is, we replace r by r = |r| in Eqs. (13) and (14). The electric field also has a spherical symmetry, so that E(r) = E(r) r r .…”

Section: Osmotic Pressurementioning

confidence: 99%

Donnan equilibrium and the osmotic pressure of charged colloidal lattices

1998

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We consider a system composed of a monodisperse charge-stabilized colloidal suspension in the presence of monovalent salt, separated from the pure electrolyte by a semipermeable membrane, which allows the crossing of solvent, counterions, and salt particles, but prevents the passage of polyions. The colloidal suspension, that is in a crystalline phase, is considered using a spherical Wigner-Seitz cell. After the Donnan equilibrium is achieved, there will be a difference in pressure between the two sides of the membrane. Using the functional density theory, we obtained the expression for the osmotic pressure as a function of the concentration of added salt, the colloidal volume fraction, and the size and charge of the colloidal particles. The results are compared with the experimental measurements for ordered polystyrene lattices of two different particle sizes over a range of ionic strengths and colloidal volume fractions.

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“…[3][4][5][6][7][8] The difficulty of setting up a predictive theory of protein suspensions based on what is known about the interaction between two proteins has been acknowledged for some time. 9 Best fitting of the osmotic pressure of, for instance, bovine serum albumin up to 100 g/1, leads to effective excluded volumes whose behavior as a function of salt is enigmatic. 10 In recent years, there has been a tendency to forget about all details of the protein interaction altogether-both attractive and repulsive-and to introduce a single adhesion parameter.…”

Section: Introductionmentioning

confidence: 99%

Optimized Baxter model of protein solutions: Electrostatics versus adhesion

Prinsen

Odijk

2004

The Journal of Chemical Physics

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A theory is set up of spherical proteins interacting by screened electrostatics and constant adhesion, in which the effective adhesion parameter is optimized by a variational principle for the free energy. An analytical approach to the second virial coefficient is first outlined by balancing the repulsive electrostatics against part of the bare adhesion. A theory similar in spirit is developed at nonzero concentrations by assuming an appropriate Baxter model as the reference state. The first-order term in a functional expansion of the free energy is set equal to zero which determines the effective adhesion as a function of salt and protein concentrations. The resulting theory is shown to have fairly good predictive power for the ionic-strength dependence of both the second virial coefficient and the osmotic pressure or compressibility of lysozyme up to about 0.2 volume fraction.

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The osmotic pressure of concentrated protein solutions: Effect of concentration and ph in saline solutions of bovine serum albumin

Cited by 347 publications

References 41 publications

Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications

Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications

Donnan equilibrium and the osmotic pressure of charged colloidal lattices

Optimized Baxter model of protein solutions: Electrostatics versus adhesion

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