2014
DOI: 10.1016/j.tins.2014.02.007
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The other side of the histamine H3 receptor

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Cited by 79 publications
(52 citation statements)
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References 96 publications
(117 reference statements)
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“…The pharmacology of H3Rs is determined not only by their localization, but also by different splicing, with more than 20 splice variants (isoforms) having been identified (Gemkow et al,2009, Drutel et al 2001. Through G-protein coupled receptors, histamine influences the action of other neurotransmitters, including dopamine, GABA, serotonin and glutamate (Ellenbroek and Ghiabi, 2014). Epilepsy represents another possible indication because histamine influences many neurotransmitters, and changes in histaminergic transmission may affect seizure threshold.…”
Section: Planned Studiesmentioning
confidence: 99%
“…The pharmacology of H3Rs is determined not only by their localization, but also by different splicing, with more than 20 splice variants (isoforms) having been identified (Gemkow et al,2009, Drutel et al 2001. Through G-protein coupled receptors, histamine influences the action of other neurotransmitters, including dopamine, GABA, serotonin and glutamate (Ellenbroek and Ghiabi, 2014). Epilepsy represents another possible indication because histamine influences many neurotransmitters, and changes in histaminergic transmission may affect seizure threshold.…”
Section: Planned Studiesmentioning
confidence: 99%
“…The release of neuronal histamine is controlled by a negative feedback, which is mediated by the presynaptic Ga i/o -coupled H 3 R (Haas et al, 2008;Schneider et al, 2014b). A growing number of reports also suggest postsynaptic functions of H 3 R (Ellenbroek and Ghiabi, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Pharmacological studies suggest histamine might be involved in the pathophysiology of schizophrenia (Arrang 2007;Tiligada et al 2011;Ellenbroek and Ghiabi 2014). The central histaminergic system, which originates in the tuberomammillary nucleus and projects across the entire brain (Panula et al 1984;Watanabe et al 1984), is associated with arousal, appetite, recognition and learning, and other processes (Huston et al 1997;Brown et al 2001;Haas and Panula 2003;Raber 2007;Haas et al 2008).…”
Section: Introductionmentioning
confidence: 99%