“…The pharmacology of H3Rs is determined not only by their localization, but also by different splicing, with more than 20 splice variants (isoforms) having been identified (Gemkow et al,2009, Drutel et al 2001. Through G-protein coupled receptors, histamine influences the action of other neurotransmitters, including dopamine, GABA, serotonin and glutamate (Ellenbroek and Ghiabi, 2014). Epilepsy represents another possible indication because histamine influences many neurotransmitters, and changes in histaminergic transmission may affect seizure threshold.…”