We examine the relation between twisted versions of the extended supersymmetric gauge theories and supersymmetric orbifold lattices. In particular, for the N = 4 SYM in d = 4, we show that the continuum limit of orbifold lattice reproduces the twist introduced by Marcus, and the examples at lower dimensions are usually Blau-Thompson type. The orbifold lattice point group symmetry is a subgroup of the twisted Lorentz group, and the exact supersymmetry of the lattice is indeed the nilpotent scalar supersymmetry of the twisted versions. We also introduce twisting in terms of spin groups of finite point subgroups of R-symmetry and spacetime symmetry.