The outcome of intravenous and inhalation anesthesia after pancreatic cancer resection: a retrospective study

Abstract

Background Different types of anesthesia may affect cancer patient’s outcomes, we compared the overall survival (OS) and disease-free survival (DFS) of patients with pancreatic cancer under total intravenous and inhalation anesthesia. Methods The authors collected the electronic medical records of patients who had accepted at a pancreatectomy from January 1, 2010 to December 31, 2016. Patients respectively received total intravenous anesthesia (TIVA) or inhalational anesthesia (INHA). Stabilized inverse probability of treatment weighting (SIPTW)was used to minimize differences. Kaplan–Meier survival was established to analyze the influence of sort of anesthesia on disease-free and overall survival. We compare the effects of each sort of anesthesia on cancer recurrence or metastasis and all-cause mortality. Results A total of 463 patients who had undergone pancreatic cancer resection were collected in this study, of which 421 patients were available (TIVA group, n = 114 INHA group, n = 307). After SIPTW there were no significant differences between the two groups in disease-free survival (hazard ratio, 1.01, 95%CI, 0.78 to 1.29, P = 0.959) or overall survival (hazard ratio, 1.11, 95%CI, 0.87 to 1.42, P = 0.405). Conclusions In conclusion, the present study showed no significant difference in overall survival and disease-free survival between total intravenous anesthesia and volatile anesthesia.

Effects of anesthesia on long-term survival in cancer surgery: A systematic review and meta-analysis

“…Forty-two retrospective cohort studies and two RCTs with a total of 686,923 patients were included in this study [ [19] , [20] , [21] , [22] , [23] , [24] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] ]. Thirty-five trials were single-center studies [ 19 , [21] , [22] , [23] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [50] , [51] , …”

“…Types of cancer surgery and inhalation anesthetics varied between studies. In total, two studies enrolled participants undergoing surgery for glioblastoma [ 47 , 56 ], one study for oral cancer [ 63 ], nine studies for breast cancer [ 34 , 37 , 42 , 45 , 49 , 53 , 59 , 61 , 71 ], five studies for non-small cell lung cancer [ 38 , 55 , 60 , 65 , 69 ], two studies for esophageal cancer [ 36 , 68 ], four studies for gastric cancer [ 40 , 44 , 50 , 57 ], five studies for colorectal cancer [ 34 , 39 , 48 , 54 , 62 ], four studies for hepatobiliary cancer [ 19 , 41 , 43 , 51 ], two studies for pancreatic cancer [ 52 , 64 ], two studies for gynecological cancer [ 21 , 22 ], two studies for urological cancer [ 23 , 58 ], one study for osteosarcoma [ 66 ], and six studies for various cancers [ 20 , 24 , 35 , 46 , 68 , 70 ]. For inhalation anesthetics, seventeen studies used sevoflurane to maintain anesthesia [ 19 , 21 , 34 , 38 , 40 , [47] , [48] , [49] , 53 , 59 , [62] , [63] , [64] , …”

“…For inhalation anesthetics, seventeen studies used sevoflurane to maintain anesthesia [ 19 , 21 , 34 , 38 , 40 , [47] , [48] , [49] , 53 , 59 , [62] , [63] , [64] , [65] , 67 , 70 , 71 ], nine studies used desflurane [ 22 , 39 , [41] , [42] , [43] , 50 , 52 , 56 , 66 ] and eighteen studies administered various inhalation anesthetics [ 20 , 23 , 24 , [35] , [36] , [37] , [44] , [45] , [46] , 51 , 54 , 55 , 57 , 58 , 60 , 61 , 68 , 69 ]. Twenty-six studies included elective surgery [ 19 , 21 , 22 , 36 , [38] , [39] , [40] , [41] , 43 , 44 , [46] , [47] , [48] , [50] , [51] , [52] , [53] , 56 , 60 , [62] , [63] , …”

Propofol-based intravenous anesthesia is associated with improved survival outcomes after major cancer surgery: a nationwide cohort study in South Korea

“…Moreover, a national Danish registry study showed that propofol-based TIVA is associated with better survival outcomes after colorectal cancer surgery [28]. However, other previous studies reported no association between propofol-based TIVA and mortality after gastric and pancreatic cancer surgery [29,30]. Further This article is protected by copyright of Korean Journal of Anesthesiology.…”

Outcomes of intravenous and inhalation anesthesia on patients undergoing esophageal cancer surgery: a retrospective observational study

“…Whether different anesthetics can affect the prognosis of tumor patients is still controversial. In a retrospective study of the overall survival of pancreatic cancer patients with different anesthesia methods showed TIVA and IHNA for improved OS in pancreatic patients or DFS was not significant [ 11 ]. Another study showed that TIVA was not significantly associated with a reduction in overall 1-year mortality or cancer-related mortality after gastric cancer surgery compared to IHNA [ 12 ].…”