The Outcome of Pregnancy After Gonadotrophin Therapy

Abstract

AND SummaryOne hundred and ten women conceived 143 times following induction of ovulation by gonadotrophins. The abortion rate was 21 per cent. Some bleeding occurred in 38 -7 per cent of pregnancies and 54 per cent of them ended in abortion. For the 112 pregnancies reaching 20 weeks, the multiple pregnancy rate was 26.8 per cent (21 twins, 5 triplets, 3 quadruplets and 1 sextuplet). Hypertension was present in 8.9 per cent of patients and in 3 -3 per cent of those with multiple pregnancy. The length of gestation was related to the number of fetuses at birth and postmaturity did not occur. The Caesarean section rate was 32.1 per cent. The birth weight of the infants was normal and the male to female sex ratio was 0.64 for singleton births and 0.78 for twins. The fetal loss was 15.9 per cent (7.1 per cent for pregnancies of over 28 weeks). Growth and development of the children were apparently normal. The incidence of all congenital malformations was 7 per cent. Thompson, S. R., and Hansen, L. M. (1970): Fertility and Sterility, 21, 844, Tricomi, V., Serr, D. M., and Solosh, G. (1960): American Journal of Obstetrics and Gynecology, 79, 504.

Minimal stimulation protocol for use with intrauterine insemination in the treatment of infertility

“…In the present prospective study all pregnancies in minimal stimulation and 95% in the conventional stimulation protocol were singleton. Pregnancies following hMG stimulations have been reported to have an increased risk of spontaneous abortion with a range of 12–31% 15,16 . Pregnancy wastage in minimal stimulation group was 5.7% only and it was 23% in the conventional stimulation group in this study.…”

“…Pregnancies following hMG stimulations have been reported to have an increased risk of spontaneous abortion with a range of 12-31%. 15,16 Pregnancy wastage in minimal stimulation group was 5.7% only and it was 23% in the conventional stimulation group in this study. With the conventional stimulation with multiple hMG injections, premature leutinizing hormone surge plays a significant adverse role.…”

The use of drugs in mothers of offspring with neural‐tube defects

“…Human chorionic gonadotrophin did not increase the incidence of CA's in 110 pregnancies following induction of ovulation by gonadotrophins. 40 No reports linking the use of lynestrenol, a progestogenic hormone with CA's, have been located 41 but its use during pregnancy is not recommended because of a possible association with CAs. The preconceptional or early post-conceptional use of chorionic gonadotrophin suggested some, but not significant association with NTD.…”

Induction of fetal lung maturation with intra‐amniotic thyroxine in multiple pregnancy

“…Since the duration of gestation and the birth weight decrease as the number of fetuses increases (McKeown and Record, 1952) siblings from multiple pregnancies are especially at risk since the average gestational age for triplets at the time of delivery is 33 weeks (Caspi et al, 1976). The need for individual management of each fetus in a multiple pregnancy is still a matter of controversy, with those in favour claiming that knowledge of the state of lung maturity of one fetus is insufficient for accurate prediction of the lung maturity of the others.…”