The oxidant/antioxidant equilibrium in horses

Kirschvink, Nathalie; Moffarts, Brieuc de; Lekeux, Pierre

doi:10.1016/j.tvjl.2007.07.033

Cited by 129 publications

(121 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, 2 groups (each ten horses) were injected with 15 mg/kg sodium selenite and 30 mg/kg ascorbic acid every 24 h for successive 4 weeks. The present result is supported by the suggestion of Kirschvink et al (36) who reported that the beneficial effect of antioxidants supplementation on the oxidant/ antioxidant equilibrium should only be expected after a few weeks of its supplementation. Regarding the antioxidant enzymes activity, GR activity was significantly decreased after sodium selenite and ascorbic acid supplementation.…”

Section: Effect Of Antioxidant Supplementationsupporting

confidence: 90%

“…GST and CAT activities were increased after antioxidant supplementation. This act may be due to increase and modulation of cellular glutathione redox system due to sparing effect of vitamin E on glutathione utilization for the scavenging of lipid peroxidation reactions (36,37,38). In order to confirm the hypothesis that airways inflammation (39) and hyper-responsiveness observed in equine passively sensitized bronchi could be related to an increased production of ROS, Matera et al evaluated the effects of a pretreatment with GSH on either nonsensitized or passively sensitized bronchi.…”

Section: Effect Of Antioxidant Supplementationmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Recurrent Airway Obstruction (RAO) on Selected Antioxidants in Horses

Borowicz

Kubiak

Nikolovski³

et al. 2016

Macedonian Veterinary Review

View full text Add to dashboard Cite

The aim of this review was to collect the most important data on the characteristics of selected antioxidants in horses with recurrent airway obstruction (RAO). RAO is one of the most common respiratory diseases in horses. This disease can not be cured, but we can try to stop its progression. It is not exactly known, what is the real contribution of antioxidants in the pathology of recurrent airway obstruction. Many researchers investigated the possibility of using antioxidant supplementation in horses with RAO.

show abstract

Section: Effect Of Antioxidant Supplementationsupporting

confidence: 90%

Section: Effect Of Antioxidant Supplementationmentioning

confidence: 99%

Impact of Recurrent Airway Obstruction (RAO) on Selected Antioxidants in Horses

Borowicz

Kubiak

Nikolovski³

et al. 2016

Macedonian Veterinary Review

View full text Add to dashboard Cite

show abstract

“…As estimated previously (Kirschvink et al 2008), in horses in some pathological processes including RAO, grass sickness and equine motor neuron disease an inflammatory process was correlated with oxidative stress. Under these conditions MDA was used as a marker of such inflammatory status.…”

Section: Transport Induced Inflammatory Responses In Horsessupporting

confidence: 60%

Transport induced inflammatory responses in horses

Wessely-Szponder¹,

Bełkot²,

Bobowiec³

et al. 2015

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Deleterious response to road transport is an important problem in equine practice. It determines different physiological, immunological and metabolic changes which lead to increased susceptibility to several disorders such as pneumonia, diarrhea, colics, laminitis, injuries and rhabdomyolisis. The aim of our study was to look for possible relationships between transportation of female young and older horses over a long and short distance and an inflammatory state reflected by an increase of acute phase protein concentration, oxidative stress and muscle injury. The study was conducted on 24 cold-blooded female horses divided into four groups. Six fillies aged 6-18 months and six mares aged 10-12 years were transported over the distance of about 550 km, six fillies aged 6-18 months and six mares aged 10-12 years were transported over the distance of about 50 km. Plasma and serum were obtained from blood samples taken before transportation (T0), immediately after transportation (T1) and at an abattoir during slaughter (T2). In these samples fibrinogen, MDA, AST and CK were assessed. Fibrinogen increased in all studied groups especially in fillies after long distance transportation, where it reached 205±7.07 mg/dl before transportation, 625±35.35 mg/dl after transportation, and 790±14.14 mg/dl during slaughter. MDA concentrations rose after transportation and reached the maximal level during slaughter. CK activity was more elevated after short transportation in younger horses, whereas initial activity of AST was higher in older horses. We estimated that intensified responses from acute phase, oxidative stress and muscle injury parameters indicated an inflammatory state.

show abstract

“…Oxidative stress has been defined as an imbalance between oxidants/antioxidants, prompting damage and death (Halliwell and Gutteridge, 1989;Sies, 1991;Kirschvink et al, 2008). Organisms are constantly exposed to exogenous and endogenous ROS and reactive nitrogen species (RNS) such as nitric oxide and superoxide anions (Moslen, 1994;Niviere and Fontecave, 1995;Kowaltowski and Verseci, 1999;Kirschvink et al, 2008).…”

mentioning

confidence: 99%

“…This response is systemic and includes enhancement of antioxidant systems and the reduction of oxidative damage due to changes in redox homeostasis (Radak et al, 2008). On the other hand, although training increases the antioxidant defence system of the organism, prolonged periods of training may cause disturbances in the oxidant/antioxidant equilibrium (Avellini et al, 1995;De Moffarts et al, 2005;Kirschvink et al, 2008).…”

mentioning

confidence: 99%

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

View full text Add to dashboard Cite

ABSTRACT:The aim of this study was to evaluate the effect of aerobic training (16 weeks -T1 and 24 weeks -T2) on oxidative stress biomarkers. To this end, GSH, GSH-peroxidase (GSH-Px) and catalase (CAT) activity were analysed in plasma. Nine bulls (3-4 years), were included in this work. The exercise training protocol was performed in a track ("taurodromo") three days per week for 24 weeks and consisted of 400 m warming up, 1200 m to 4-5 m/s, two minutes' resting, 1200 m to 4-5 m/s and, finally, 400 m walking. The results reflected that GSH-Px activity was higher at T1 (6.18 ± 0.45) than at baseline (T0; 2.31 ± 0.08) while the GSH level (2.98 ± 0.37) was lower vs. T0 (14.59 ± 3.40). Moreover, there were significant increases in GSH-Px (18.23 ± 1.36) and CAT (2.52 ± 0.04) activities and the recovery of basal values in GSH (11.75 ± 2.84) in T2. In conclusion, the type of training carried out in this study involved two well-defined stages: (i) a period of perturbation, followed by (ii) adaptation. The former stage was characterised by the induction of oxidative stress manifested as a decrease in the GSH, and the latter (T2) by the recovery of this non-enzymatic antioxidant.

show abstract

The oxidant/antioxidant equilibrium in horses

Cited by 129 publications

References 105 publications

Impact of Recurrent Airway Obstruction (RAO) on Selected Antioxidants in Horses

Impact of Recurrent Airway Obstruction (RAO) on Selected Antioxidants in Horses

Transport induced inflammatory responses in horses

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Contact Info

Product

Resources

About