The P300 Component of the Auditory Event-Related Potential: Interlaboratory Consistency and Test-Retest Reliability.

Abstract

Approved for public release; distribution is unlimited.Navy Personnel Rese-,. 6 and Development Uenter San Diego, California 92152-6800REPORT DOCUMENTATION PAGE Oo.070rov18Public reporng burden for this collction of i wfr wan is stana to avrage I hour per rpone mcuing the tine for reviewmg uitsuccoes, searting easting data souc. gaidng and maintaiing the dats needed, and crmnplaeng and reviewing thecoflcuion of infornsaum. Sed oannuis regarding this burden sui nste or my other Approved for public release; distribution is unlimited. ABSTRACT (Maximum 200 words)The auditory evoked potential in a signal classification task using rare and frequent tones was measured by four independent laboratories, to assess the test-retest reliability and interlaboratory consistency of the P300 component. Across laboratories, 61 male subjects (three samples of military subjects, n = 25, n = 18, and n = 8; one sample of college students, n = 10), ranging between 18 and 49 years of age were tested. With few exceptions, all experimental and subject factors were controlled. At each of three electrode sites (Fz, Cz, and Pz), peak amplitude, peak latency, and root-mean-square amplitude (RMS), of the P300 were computed for each subject in test and retest conditions. Statistical analyses of the data supported three strong inferences: (1) test-retest reliability and interlaboratory consistency of P300 measures is high for RMS amplitude, lower for peak amplitude, and lowest for peak latency; (2) recordings from site Pz provide higher reliability and consistency than sites Fz or Cz; (3) the RMS amplitude of P300 is negatively correlated with reaction time to correctly classify rare tones. The data support the notion that ERP components, such as P300, can be reliably measured by different laboratories, with a test-retest correlation coefficient of 0.8 or higher. SUBJECT TERMS NUMBER OF PAGESPhysiological metrics -yrchnnhy,,',-,-q7y -vr-rlanttM rntentinl'c PW.0 c,:,PCrnt. FOREWORDThis report describes experiments performed under the project Biopsychometric Assessment of Combat Operations or BIOPS (PE 0602234N, Task RS34H21), in order to verify procedural uniformity of the laboratories that are performing electrophysiological recording of event-related potentials (ERPs). The experiments involved the presentation of sequences of auditory stimuli (tone bursts of two frequencies) that elicit a positive-going wave in the ERP known as the P300 component. The laboratories were the Navy Personnel Research and Development Center (NPRDC), the Naval Aerospace Medical Research Laboratory (NAMRL), the Naval Health Research Center (NHRC), and the ERP laboratory of the Neurosciences Department at the University of California, San Diego (UCSD). The research was sponsored by the Office of Naval Technology.The results of the experiments show that, with minor exceptions, the laboratories involved in the BIOPS project have achieved the level of procedural uniformity required to allow for independent advanced investigations in later phases of the project. Further...

Immediate effects and duration of a short and single application of transcutaneous auricular vagus nerve stimulation on P300 event related potential

“…Our RT data shortened significatively, immediately from the initial stimulation period to the t21–28m time period, and then returned to pre-stimulation values in subsequent attempts, which is likely to be a direct effect of stimulation rather than a learning effect after repeated exposure to the target stimulus along the blocks. Research on the relationship between RT and P300 indicates that in a simple oddball task, RT occurs about 50 ms before the peak of the P300 ERP ( Picton, 1992 ) and P300 latency correlates with RT ( Trejo et al, 1991 ) as observed in the present experimental conditions.…”

Brain vital sign monitoring of sleep deprivation detects situational cognitive impairment

“…In addition, 0.8 is the estimated minimum test-retest correlation coefficient reported by Trejo et al (1991) in a study of auditory evoked potentials using rare and frequent tones.…”