The p48 subunit of the damaged-DNA binding protein DDB associates with the CBP/p300 family of histone acetyltransferase

Datta, Abhishek; Bagchi, Srilata; Nag, Alo; Shiyanov, Pavel; Adami, Guy R.; Yoon, Taewon; Raychaudhuri, Pradip

doi:10.1016/s0921-8777(01)00082-9

Cited by 125 publications

(85 citation statements)

References 27 publications

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“…Other studies suggested a role of DDB in recruiting chromatin-remodeling proteins onto UVdamaged chromatin. DDB has been shown to associate with the CBP/p300 family of histone acetyl transferase (Datta et al, 2001). In this regard, DDB is similar to the base excision repair protein thymine DNA glycosylase, TDG, which was shown to associate with CBP/p300 (Tini et al, 2002).…”

Section: Ddb2-deficient Mice Develop Spontaneous Tumorsmentioning

confidence: 99%

“…DDB2 associates with the transcriptional activator protein E2F1 (Hayes et al, 1998). Moreover, DDB2 also associates with the transcriptional coactivator proteins CBP/p300 and the STAGA complex (Datta et al, 2001;Martinez et al, 2001). The association with CBP/p300 and the STAGA complex suggests a role of DDB2 in chromatin remodeling and that might explain its repair and transcription functions.…”

Section: Introductionmentioning

confidence: 99%

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Tumor-prone phenotype of the DDB2-deficient mice

et al. 2004

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DDB2 is an essential subunit of the damaged-DNA recognition factor DDB, which is involved in global genomic repair in human cells. Moreover, DDB2 is mutated in the repair-deficiency disease xeroderma pigmentosum (Group E). Expression of DDB2 in human cells is induced by P53, BRCA1 and by ionizing radiation. The DDB2 protein associates with transcriptional activator and coactivator proteins. In addition, DDB2 in conjunction with DDB1 associates with cullin 4A and the Cop9/signalosome. We generated a mouse strain deficient for DDB2 (DDB2À/À). Consistent with the human disease (XP-E), the DDB2À/À mice were susceptible to UV-induced skin carcinogenesis. We observed a significant difference in the initial rate of cyclobutane pyrimidine dimer (CPD)-removal from the skin following UV irradiation. Also, the DDB2-deficient mice exhibited a significantly reduced life span compared to their wild-type littermates. Moreover, unlike other XP-deficient mice, the DDB2-deficient mice developed spontaneous malignant tumors at a high rate between the ages of 20 and 25 months. The observations suggest that, in addition to DNA repair, the other interactions of DDB2 are significant in its tumor suppression function.

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Section: Ddb2-deficient Mice Develop Spontaneous Tumorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tumor-prone phenotype of the DDB2-deficient mice

et al. 2004

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“…16 XPE interacts with a variety of proteins to modulate cellular responses to DNA damage. Interactions between XPE and the CBP/p300 17,18 and STAGA 18,19 chromatin remodeling complexes also are critical for the efficient removal of damage by the GG-NER pathway. These complexes acetylate histones, thereby relaxing the local chromatin superstructures to allow access to the DNA for processes such as repair or transcription.…”

Section: Finding Dna Damage: Xpa Xpc and Xpementioning

confidence: 99%

Other Proteins Interacting with XP Proteins

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Molecular Mechanisms of Xeroderma Pigmentosum

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“…In fact, inactivation of GCN5 in human cells decreases recruitment of NER factors to damaged sites, which demonstrates that GCN5 is important for a timely and efficient NER [38]. Besides, UV-DDB complex (DDB1-DDB2) recruits two HATs, such as CBP/p300 and STAGA (a SAGA-like complex containing GCN5L) [39,40], whose activities induce chromatin remodeling to allow recruitment of the repair complexes at the UVC-induced damage sites. By the same token, it has also been observed that p33ING2, a member of the inhibitor of growth (ING) family proteins, enhances NER in a p53-dependent manner by inducing chromatin relaxation following UVC irradiation, increased acetylation of histone H4 and recruitment of NER factors to sites of damage [41].…”

Section: Histone Acetylationmentioning

confidence: 99%