The p53 codon 72 polymorphism and susceptibility to colorectal cancer in Korean patients

Abstract

TP53 is a major gene involved in the determination of proliferation or growth arrest at the cellular level. The polymorphism of p53 at codon 72 has been widely studied; this variation has been associated with cancer susceptibility and disease outcome. The specific aim of this study was to investigate whether the p53 codon 72 polymorphism is associated with individual susceptibility to colorectal cancer in Korean patients. The frequency of the polymorphism was examined in 156 patients with colorectal cancer and in 293 healthy controls. The polymorphism analysis was performed by amplifying exon 4 of p53 and digesting the products with restriction enzyme. The frequencies of genotypes: Arg/Arg, Arg/Pro and Pro/Pro were 34.6% (54/156), 43.0% (67/156) and 22.4% (35/156), respectively, in the cases with colorectal cancer, and 28.9% (114/293), 47.8% (140/293) and 13.3% (39/293), respectively, in the healthy controls. Statistically, there was a significant difference in the frequency of the genotypes when the healthy controls were compared to the patients with colorectal cancer (p=0.0459). The specific allele frequencies showed borderline significance (p=0.0502). Our findings suggest that the p53 Pro72 variant is associated with an increased risk for colorectal cancer in the Korean population.

Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population

“…Genotype p53 Arg72Pro as well as younger patients have decreased CRC risk in comparison to Pro72Pro and older age group of patients (0.14; 95% CI 0.02-0.99, p=0.049). Our results are consistent with the recent published studies [12,13,[42][43][44]. Few other studies have reported contradictory findings, e.g.…”

p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

“…From North India, association of Pro/Pro genotype with the increased risk of breast cancer (Sayeed et al, 2010), colorectal cancer and urinary bladder cancer (Pandith et al, 2010) has been previously reported in Kashmiri population inhabiting a mountainous region. Association of Pro allele with increased risk of colorectal cancer has been reported in Japanese population (Hamajima et al, 2002), Korean population (Cao et al, 2009), in Chinese (Zhu et al, 2007) and in Malaysian population (Aizat et al, 2011). But for breast cancer risk no association of p.R72P polymorphism have been reported in Tunisian (Mabrouk et al, 2003) and Russian subjects (Suspitsin et al, 2003).…”

Polymorphisms of cell cycle regulator genes CCND1 G870A and TP53 C215G: Association with colorectal cancer susceptibility risk in a Malaysian population

“…The change of amino acid from arginine to proline in a proline-rich region of the protein may affect the role of p53 in apoptosis (13). To date, a small number of case-control studies have been conducted to investigate the potential association of the CCND1 G870A and TP53 C215G polymorphisms with CRC susceptibility risk in various populations (14,15). However, no reports are available from Malaysian populations.…”