The PAIN Study: Paracetamol, Aspirin and Ibuprofen New Tolerability Study

Moore, Nicholas; Ganse, Éric Van; Parc, Jean-Marie Le; Wall, Richard A.; Schneid, H; Farhan, Mahdi; Verrière, François; Pelen, F.

doi:10.2165/00044011-199918020-00001

Cited by 133 publications

(37 citation statements)

References 21 publications

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“…In the meantime, symptomatic pain relief can be obtained with analgesics such as paracetamol, or the more effective non-steroidal anti-inflammatory drugs (NSAIDs) [1-3]. NSAIDs, while generally safe when used at low doses and short term [4-6], can result in serious complications (gastrointestinal bleeding, renal failure, coronary heart disease) when used long-term or at higher doses in elderly patients, which is often the case in patients with osteoarthritis [7-9]. Different products have been proposed for long-term symptomatic relief of osteoarthritis, some of them purporting to have some chondroprotective effects, such as chondroitin sulphate, diacerhein or glucosamine [10-13].…”

Section: Introductionmentioning

confidence: 99%

Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial

et al. 2009

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IntroductionThe medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks. Complementary medicines might reduce the symptoms of OA and decrease the need for NSAIDs. This study tested the effects of a food supplement, Phytalgic®, on pain and function in patients with osteoarthritis and their use of analgesic and NSAIDs.MethodsA randomized double-blind parallel-groups clinical trial compared Phytalgic® (fish-oil, vitamin E, Urtica dioica) to a placebo for three months, in 81 patients with OA of the knee or hip using NSAIDs and/or analgesics regularly. The main outcome measures were use of NSAIDs (in Defined Daily Doses per day - DDD/day) or analgesics (in 500 mg paracetamol-equivalent tablets per week (PET/week) measured each month, and Western Ontario-McMaster University Osteo-Arthritis Index (WOMAC) function scales.ResultsAfter three months of treatment, the mean use of analgesics in the active arm (6.5 PET/week) vs. the placebo arm (16.5) was significantly different (P < 0.001) with a group mean difference of -10.0 (95% CI: -4.9 to -15.1). That of NSAIDs in the active arm (0.4 DDD/day) vs the placebo arm (1.0 DDD/day) was significantly different (P = 0.02) with a group mean difference of - 0.7 DDD/day (95% CI: -0.2 to -1.2). Mean WOMAC scores for pain, stiffness and function in the active arm (respectively 86.5, 41.4 and 301.6) vs the placebo arm (resp. 235.3, 96.3 and 746.5) were significantly different (P < 0.001) with group mean differences respectively of -148.8 (95% CI: -97.7 to -199.9), -54.9 (95% CI: -27.9 to -81.9) and -444.8 (95% CI: -269.1 to -620.4).ConclusionsThe food supplement tested appeared to decrease the need for analgesics and NSAIDs and improve the symptoms of osteoarthritis.Trial registrationClinicaltrials.gov NCT00666523.

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Section: Introductionmentioning

confidence: 99%

Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial

et al. 2009

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“…Ibuprofen besitzt eine höhere analgetische Potenz als Paracetamol [2,21]. Dabei treten leichte unerwünschte Nebenwirkungen am Magendarmtrakt bei kurzfristiger Anwendung von Paraceta-mol und Ibuprofen gleich häufig auf.…”

Section: Otitis Mediaunclassified

Schmerztherapie bei akuten pädiatrischen Erkrankungen und Impfungen

2000

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PHENOMENON PAIN: While pain is one of the main reasons for an unscheduled visit to the paediatrician, pain due to painful procedures is of major importance in scheduled visits. Actual pain therapy is illustrated in the treatment of burns. Incomplete analgesia may have an unfavourable impact on morbidity and mortality. The pain score does not correlate with the extent of the burned area, and is regularly underestimated. General anaesthesia or analgo-sedation are warranted during the care of the burned patient. INSUFFICIENT ANALGESIA: Consequence of insufficient analgesia during primary care is an increased need of analgesics, and an increased pain treatment failure rate during subsequent procedures. Pain is interfering with anxiety, sleep disturbances and post-traumatic psychologic alterations. All those symptoms must be treated adequately. ACUTE ILLNESS AND INJECTIONS: This article covers pain from otitis media, pharyngitis, Guillain-Barré syndrome, purpura fulminans, Toxic Epidermal Nekrolysis, as well as the usage of local anaesthesia during injections, not to forget the application of non-pharmacologic methods for pain therapy and prophylaxis.

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“…The topical effects are particularly important for the short‐term damage while the systemic effects may be more important for the more serious long‐term adverse effects. Serious outcomes were not evident in a large number of subjects on OTC doses of ibuprofen or naproxen, but reliable serious outcome assessments would need to take account of the fact that there may only be one or two such events per hundred thousand subjects taking these drugs …”

Section: Introductionmentioning

confidence: 99%

“…A meta‐analysis of eight placebo‐controlled trials showed that gastrointestinal tolerability with OTC doses of ibuprofen (87.9%) did not differ significantly from placebo (89%) . A number of well‐designed studies confirm this apparent good gastrointestinal tolerability . However, these studies do not take account of the different formulations of NSAID ingested, which have different physicochemical properties and consequently different pharmacokinetic and pharmacodynamic profiles.…”

Section: Introductionmentioning

confidence: 99%