Dear Editor, The COVID-19 pandemic has starkly exposed deep-rooted inequities and vulnerabilities in our global health systems. These deficiencies disproportionately affect marginalized populations, such as racial and ethnic minorities, key populations of HIV, indigenous communities, people with disabilities and economically disadvantaged individuals [1][2][3]. An accord by the World Health Organization (WHO), known as the 'pandemic treaty' or WHO CA+, seeks to address these deficiencies. This treaty is currently under development by the Intergovernmental Negotiating Body (INB) [4]. In response to the international community's perceived failure in demonstrating solidarity and equity during the pandemic, the treaty's Zero Draft is being prepared as a comprehensive strategy for future pandemic prevention, preparedness and response [4]. As it stands, negotiations are ongoing, with the new instrument expected to be adopted at the World Health Assembly in May 2024 [4]. Despite the draft acknowledging the importance of addressing the needs of underserved communities, it is vital that actions match rhetoric through the active involvement of these communities in the process [4]. The rights and needs of vulnerable populations must be an integral part of the process throughout all stages. Notably, equity considerations, as highlighted by several advocates, seem to be insufficiently addressed in the current Zero Draft and need to be better incorporated [5].The COVID-19 pandemic has resulted in higher infection, hospitalization and mortality rates in minority communities, compared to the general population [6]. Barriers to healthcare access and other vital resources for vulnerable communities have been further amplified due to the pandemic. In the United States, for example, Black, Hispanic and Native American individuals are more likely to contract COVID-19 and suffer severe outcomes, a disparity attributed to systemic racism, poor access to healthcare and a higher prevalence of underlying health conditions among these communities [7]. In the early days of the pandemic, the urban slums have seen more COVID-19 infections than non-slum areas in some settings, due to factors like overcrowding, limited healthcare and sanitation access and difficulties in physical distancing practices [8]. An apt illustration of global health inequity is seen in the distribution of COVID-19 vaccines, where wealthy nations have hoarded the lion's share, leaving poorer countries struggling for access. Within these disadvantaged nations, marginalized communities, including ethnic and racial minorities, are further isolated, frequently facing barriers to accessing these crucial vaccines [9]. In Africa, the COVID-19 pandemic has exacerbated existing inequities experienced by marginalized groups in under-resourced areas, compounded by poor housing, limited healthcare access and inadequate water and sanitary facilities [3]. A critical step towards addressing these disparities is to protect these communities from further marginalization in global health...