The Panomat® P-10 micro-volumetric infusion pump is suitable for continuous drug administration at minimal flow rates

Abstract

P Pu ur rp po os se e: : To evaluate the performance of the Panomat® P-10 micro-volumetric infusion pump for its use in drug administration at minimal flow rates (µL·hr -1 ; e.g., intrathecal application).M Me et th ho od ds s: : Fluid delivery at steady state conditions, and after vertical displacement of the syringe pump by -50 cm was determined gravimetrically. The Panomat® P-10 infusion pump was evaluated at 4, 10, 20, 50 and 100 µL·hr -1 , and compared to a conventional syringe pump assembly at 100, 200, 500 and 1000 µL·hr -1 . Measurements were repeated twice with two different devices of each syringe pump system, and with two syringes. Data are reported as mean ± SD. R Re es su ul lt ts s: : Steady state fluid delivery of the Panomat® P-10 infusion pump revealed less than 5% deviation to set flow rate at 10, 20, 50 and 100 µL·hr -1 , and 12% deviation at 4 µL·hr -1 . Mean zero-drug delivery time (ZDDT) after lowering the pump by 50 cm at 4 µL·hr -1 flow rate was 38.4 ± 7.3 min. At 100 µL·hr -1 and with original infusion line ZDDT was almost 20 times shorter when compared to the conventional syringe pump assembly (1.5 ± 0.5 min vs 28.5 ± 5.0 min). C Co on nc cl lu us si io on n: : The tested Panomat® P-10 micro-volumetric pump shows an acceptable flow accuracy as well as a low susceptibility to vertical displacement, and is therefore suitable for continuous drug administration at minimal flow rates. The technology used in this pump carries potential implications for a new generation of syringe pumps. (1,5 ± 0,5 min vs 28,5 ± 5,0 min Objectif

In Vitro Evaluation of Hydraulic Characteristics of Prototype Implantable Intrathecal Infusion Pump

“…In addition, based on these experimental results, a more realistic control firmware that supports various flow rate adjustments and bolus modes will be developed in a further study. (6,7). In contrast, in an implantable device, the altitude difference is relatively small and does not change steeply after implantation.…”

Development and in vitro evaluation of a flow-adjustable elastic drug infusion pump

“…To determine the effects of the vertical altitude difference between the drug chamber and the distal end of the outlet catheter, the target injection rate was set at 0.5, 1.0, 1.5, and 2.0 ml/h, respectively, the drug chamber was abruptly dropped 50 cm under the catheter-attached needle, and the retrograde aspiration volume (RAV), zero-drug delivery time (ZDDT), and time to re-establish a 95 per cent steady-state flow were measured. The drug chamber was then abruptly raised 50 cm upwards and the release of an infusion bolus (IB) and the pattern of the actual flowrate in the same operation modes were measured [5, 7]. A patient monitor (DS-5300W; Fukuda Denshi Co. Ltd, Tokyo, Japan) and a data acquisition board (NI-USB 6250; National Instruments Corp., Austin, Texas, USA) were used to extract the information on the internal pressure of the drug chamber.…”

Syringe pump displacement alters line internal pressure and flow

“…12 Neff et al reported a reduced gravimetric influence of the Panomat® P-10 (Disetronic Medical Systems AG, Burgdorf, Switzerland) micro-volumetric infusion pump during vertical pump displacement, which was designed especially for microinfusion. 13 Although 50-mL syringes are commonly used when administering catecholamines, we chose 20-mL syringes, which are of relatively low compliance. We use 20-mL syringes in caring for neonates to improve accuracy of drug delivery when infusing catecholamines.…”