The paracaspase MALT1 is a downstream target of Smad3 and potentiates the crosstalk between TGF-β and NF-kB signaling pathways in cancer cells

Regnase-1 overexpression as a therapeutic approach of Marfan syndrome

“… 24 However, TGF-β triggers the activation of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1) paracaspase and NF-κB pathway in cancer cells. 25 Consistently, our findings prove increased MALT-1 expression in the SMCs of Marfan mice, providing mechanistic support for reduced endoribonuclease expression within the aortic wall. MALT-1 was demonstrated to induce the cleavage of regnase-1 in immune cells as a critical step for controlling T cell activation.…”

Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer

“…3d ). Previous studies have shown that SMAD3 plays an important role in tumor immune response by modulating MHC 16 , 17 , interferon signaling 18 and NFKB pathway 19 . The inhibition of TGFβ-SMAD3 signaling can sensitize immunotherapy response in melanoma 20 and pancreatic cancer 21 .…”

The NF-κB/NUAK2 signaling axis regulates pancreatic cancer progression by targeting SMAD2/3

“…The canonical TGF-β signaling pathway is mediated by SMAD transcription factors. 43 Given the observed reduction in SMAD2/3 mRNA levels in Si-NUAK2 transfected cells and the known association between the TGF-β signal and NUAK2, we speculated that the effect of NUAK2 on pancreatic cancer might be related to the regulation of SMAD pathways. The results indicated a significant decrease in the expression levels of p -SMAD2, p -SMAD3, SMAD2, and SMAD3 upon silencing NUAK2.…”