The paradigm of prophylactic viral outbreaks measures by microbial biosurfactants

Singh, Kunwarjeet; Nandi, Aditya; Sinha, Adrija; Ghosh, Aishee; Sengupta, Sarabasti; Saha, Utsa; Singh, Pawan; Panda, Pritam Kumar; Raina, Vishakha; Verma, Suresh K.

doi:10.1016/j.jiph.2023.02.016

Cited by 14 publications

(6 citation statements)

References 121 publications

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“…As mentioned before, biosurfactants have been reported as antiviral agents due to their physical properties, altering viral membrane structures and disrupting their outer covering, finally causing eradication [ 89 ]. Glycolipids are one of the groups of biosurfactants more widely studied.…”

Section: Biosurfactants As Biological Control Agentsmentioning

confidence: 99%

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Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal and antiviral effects, and antioxidant, anticancer and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formations in clinical, hygiene and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro- and nanoemulsions and hydrogels, improving drug solubility, stability and bioavailability, and enabling a targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound-healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analysing the most recent literature, this review aims to update the present understanding, highlight emerging trends, and identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.

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Section: Biosurfactants As Biological Control Agentsmentioning

confidence: 99%

“…They can enhance immunity when combined with other medications or serve as an effective solution when primary immunity against a virus is lacking. For example, surfactin possesses emulsifying properties and can serve as an immunological adjuvant in vaccines or drugs [ 89 , 126 ].…”

Section: Perspectives Of Biosurfactants For Wound-healing Anticancer ...mentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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show abstract

“…Additionally, they are found to be suitable for usage in future innovations like nanobiotechnology and effective medication delivery systems. Also, they have drawn considerable interest from the scientific community due to their strong therapeutic qualities, making them useful in the treatment of SARS-CoV infection as well as for anti-viral, immunomodulatory, anti-cancer, wound healing, and other conditions (Kumari et al 2023 ).…”

Section: Applications Of Biosurfactantsmentioning

confidence: 99%

Biotechnological potential of microbial bio-surfactants, their significance, and diverse applications

2023

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Globally, there is a huge demand for chemically available surfactants in many industries, irrespective of their detrimental impact on the environment. Naturally occurring green sustainable substances have been proven to be the best alternative for reducing reliance on chemical surfactants and promoting long-lasting sustainable development. The most frequently utilized green active biosurfactants, which are made by bacteria, yeast, and fungi, are discussed in this review. These biosurfactants are commonly originated from contaminated sites, the marine ecosystem, and the natural environment, and it holds great potential for environmental sustainability. In this review, we described the importance of biosurfactants for the environment, including their biodegradability, low toxicity, environmental compatibility, and stability at a wide pH range. In this review, we have also described the various techniques that have been utilized to characterize and screen the generation of microbial biosurfactants. Also, we reviewed the potential of biosurfactants and its emerging applications in the foods, cosmetics, pharmaceuticals, and agricultural industries. In addition, we also discussed the ways to overcome problems with expensive costs such as low-cost substrate media formulation, gravitational techniques, and solvent-free foam fractionation for extraction that could be employed during biosurfactant production on a larger scale.

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“…LABs fermentation of foods improves both the nutritional value and digestibility of the end-products (Nout, 2009 Ceresa et al, 2023) activities. Besides, due to their interesting emulsifying and surface activities, they showed ability to inactivate enveloped viruses through destabilization of membrane that enclosed vital proteins and RNA (Smith et al, 2020;Raza et al, 2022;Kumari et al, 2023). The inhibition of enzymes involved in viral replication including RNA and DNA polymerases by biosurfactants was also highlighted (Hegazy et al, 2022;Sarangi et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Biovalorization of Four Main Traditional Food Products and By-products Produced in The Adamaoua Region (Cameroon)

2024

JNFST

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Nowadays, the demand of traditional foodstuffs and by-products (Bio character) including traditional fermented milks by consumers is increased because of their numerous health benefits, important nutritional values and original organoleptic properties. A great diversity of indigenous food products that have potential functional properties is manufactured worldwide. The aim of the present work is to describe the main indigenous foodstuffs and by-products highly produced and consumed in the Adamaoua Region of Cameroon and to evocate their interesting potential functional properties, their utilizations and some related challenges. In the Adamaoua Region of Cameroon, the traditional foodstuffs produced abundantly and highly consumed are represented by four types: fermented milks (Pendidam and Kindirmou), a sun drying meat product (Kilishi) and honey bees. Pendidam and Kindirmou are dairy products produced by fermentation of raw fresh milk from cow origin. Kilishi is produced from a highly appreciated local zebu race “Goudali” meat after muscle meat cutting, trimming, slicing, sun drying, spicing and roasting operation steps successively. Honey bees are produced by exploiting local plants that confer its original taste and other organoleptic properties. All these foodstuffs are used mainly for feeding and therapeutic purposes. Thereby, the fermented milks produced in the Adamaoua Region of Cameroon are indigenous foodstuffs that cannot act only as nutrient sources but can also have potential health benefits like disease preventing or curing role. These dairy fermented products contain lactic acid bacteria (LABs) that produce a wide range of bioactive molecules such as biosurfactants that possess multiple interesting functional properties. One of the main challenges of the present study is to exploit the biosurfactants properties in fighting against diseases due to enveloped viruses (Covid-19, AIDS, Influenza, Hepatitis B and C viruses, etc.) and all their mutants, and against cardio and cerebro-vascular accidents.

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The paradigm of prophylactic viral outbreaks measures by microbial biosurfactants

Cited by 14 publications

References 121 publications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Biotechnological potential of microbial bio-surfactants, their significance, and diverse applications

Biovalorization of Four Main Traditional Food Products and By-products Produced in The Adamaoua Region (Cameroon)

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