“…The role of the two possible routes of access to the sella turcica region, i. e., the intracranial and the extracranial approaches, is well reflected in the history of pituitary surgery. Ever since the pituitary was first exposed by Fedor Krause in 1905, both neurosurgeons (Krause 1905(Krause , 1908(Krause , 1911Cushing 1912;Frazier 1913Frazier , 1916Frazier , 1928Dandy 1922Dandy , 1932Olivecrona 1941Olivecrona , 1953Grant 1948;Tönnis 1952;Krayenbiihl 1958;Guiot 1958;Guiot and Thibaut 1955;Ray and Patterson jr. 1962;Svien et al 1965) and rhinologists (Schloffer 1907;Hirsch 1910Hirsch , 1930Hirsch , 1952Hirsch , 1956Chiari 1912;Kahler 1917;Nager and Henschen 1919;Nager 1929Nager , 1936Nager , 1940Hamberger et al 1959Hamberger et al , 1961 attempted to find optimum surgical techniques, with preference alternately given to one or the other approach particularly by the neurosurgeons. While Fedor Krause was the first to use the transfrontal approach, Schlofter first opted for the trans-sphenoidal route in 1907.…”