The parental brain and behavior: A target for endocrine disruption

Keller, Matthieu; Vandenberg, Laura N.; Charlier, Thierry

doi:10.1016/j.yfrne.2019.100765

Cited by 41 publications

(37 citation statements)

References 331 publications

(318 reference statements)

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“…care could be of central importance to improve our general use and regulation of pesticides (Cummings et al, 2010;Fong-Mcmaster et al, 2020;Keller et al, 2019). To date, however, only few studies in rodents did investigate the occurrence and nature of these sublethal effects (Cummings et al, 2010;Fong-Mcmaster et al, 2020;Keller et al, 2019). Our results in earwigs thus confirm that sublethal effects of pesticides can impair the expression of maternal care in a broader number of animal species and, importantly, reveal for the first time that these effects can apply both before juveniles' emergence (i.e.…”

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

“…Studying sublethal effects of pesticides on maternal care may provide novel tools to unravel the neurobiological, physiological and/or molecular pathways regulating maternal behaviors in animals (Keller et al, 2019). This could be particularly decisive in insects, where these pathways remain poorly understood (Bridges, 2020;Körner et al, 2020;Trumbo, 2019;Wu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…suggested to be of central importance because the resulting alterations in offspring could shape the long-term efficiency of pesticide use, and the maintenance and population dynamics of nontarget organisms (Cummings et al, 2010;Fong-Mcmaster et al, 2020). To date, however, these sublethal effects on maternal care were investigated in only a few studies conducted in rats and mice (de Castro et al, 2007;Keller et al, 2019;Punzo, 2003;Stürtz et al, 2008;Udo et al, 2014;Venerosi et al, 2009). These studies showed, for example, that mothers fed with lindane (an organochlorine pesticide) exhibit a lack of retrieval behavior and a consequential litter loss (Matsuura et al, 2005), that mothers exposed to a glyphosate-based herbicide (an organophosphorus pesticide) increased maternal licking behaviors (Dechartres et al, 2019) or that mothers fed with methoxychlor (an organochloride pesticide) reduced the amount of time spent in nursing (Palanza et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Sublethal exposure to deltamethrin impairs maternal egg care in the European earwig Forficula auricularia

Meunier

Dufour²,

Meyel³

et al. 2020

Chemosphere

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The application of pesticides typically leads to lethal and sublethal exposure of non-target insects. Whereas our current understanding of these sublethal effects typically focuses on reproductive and physiological parameters, recent works emphasize that sublethal effects on behaviors such as maternal care could be of major importance in non-target species. However, it remained unknown whether these sublethal effects occur in insects. Here, we tested if exposure to sublethal doses of deltamethrin -a pyrethroid insecticide commonly used in crops -alters the expression of maternal egg care in females of the European earwig Forficula auricularia, a predator insect and pest control. Our results first reveal that deltamethrin exposure impaired the expression of three forms of maternal egg care: It decreased the likelihood of mothers to gather their otherwise scattered clutch of eggs, increased the time during which the female abandoned the clutch after a predator attack and reduced egg grooming duration. These sublethal effects did not reflect a lower activity of deltamethrin-exposed females, as these females increased their expression of self-grooming, and deltamethrin exposure did not affect females' exploration and mobility. Finally, we found that the negative effects of deltamethrin on egg care did not modify egg development, hatching rate and juvenile weight, possibly due to the transient effects of deltamethrin on maternal behaviors. Overall, our results reveal that sublethal exposure to a pesticide may diminish maternal egg care in a natural pest control and call for the integration of this measurement in assays on pesticides application.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sublethal exposure to deltamethrin impairs maternal egg care in the European earwig Forficula auricularia

Meunier

Dufour²,

Meyel³

et al. 2020

Chemosphere

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“…It has been shown that acute maternal administration of DES to rats in this period can affect the size and gene expression within the neonatal sexually dimorphic nucleus of the preoptic area [10,11]. The nuclear structures of the hypothalamus are key components, not only for the central control of the major endocrine axes but, also, via projections to other brain regions, they are critically involved in a number of important behavioral paradigms, including maternal and sexual behavior [12][13][14]. Some of the major hypothalamic genes are moreover under direct or indirect steroid control, such as those for oxytocin (Oxt) or gonadotropin releasing-hormone (GnRH).…”

Section: Introductionmentioning

confidence: 99%

Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior

Hunter

Heng

Mann

et al. 2021

IJMS

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Xenobiotic exposure during pregnancy and lactation has been linked to perinatal changes in male reproductive outcomes and other endocrine parameters. This pilot study wished to assess whether brief maternal exposure of rats to xenobiotics dibutyl phthalate (DBP) or diethylstilbestrol (DES) might also cause long-term changes in hypothalamic gene expression or in reproductive behavior of the resulting offspring. Time-mated female Sprague Dawley rats were given either DBP (500 mg/kg body weight, every second day from GD14.5 to PND6), DES (125 µg/kg body weight at GD14.5 and GD16.5 only), or vehicle (n = 8–12 per group) and mild endocrine disruption was confirmed by monitoring postnatal anogenital distance. Hypothalamic RNA from male and female offspring at PND10, PND24 and PND90 was analyzed by qRT-PCR for expression of aromatase, oxytocin, vasopressin, ER-alpha, ER-beta, kisspeptin, and GnRH genes. Reproductive behavior was monitored in male and female offspring from PND60 to PND90. Particularly, DES treatment led to significant changes in hypothalamic gene expression, which for the oxytocin gene was still evident at PND90, as well as in sexual behavior. In conclusion, maternal xenobiotic exposure may not only alter endocrine systems in offspring but, by impacting on brain development at a critical time, can have long-term effects on male or female sexual behavior.

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Enhanced maternal behaviors in a mouse model of congenital blindness

Bouguiyoud

Xie

Bronchti

et al. 2023

Developmental Psychobiology

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In mammals, mothering is one of the most important prosocial female behavior to promote survival, proper sensorimotor, and emotional development of the offspring. Different intrinsic and extrinsic factors can initiate and maintain these behaviors, such as hormonal, cerebral, and sensory changes. Infant cues also stimulate multisensory systems and orchestrate complex maternal responsiveness. To understand the maternal behavior driven by complex sensory interactions, it is necessary to comprehend the individual sensory systems by taking out other senses. An excellent model for investigating sensory regulation of maternal behavior is a murine model of congenital blindness, the ZRDBA mice, where both an anophthalmic and sighted mice are generated from the same litter. Therefore, this study aims to assess whether visual inputs are essential to driving maternal behaviors in mice. Maternal behaviors were assessed using three behavioral tests, including the pup retrieval test, the home cage maternal behavior test, and the maternal aggression test. Our results show that blind mothers (1) took less time to retrieve their offspring inside the nest, (2) spent more time nursing and licking their offspring in the second‐ and third‐week postpartum, and (3) exhibited faster aggressive behaviors when exposed to an intruder male, compared to the sighted counterparts. This study provides evidence that congenitally blind mothers show more motivation to retrieve the pups, care, and protection towards their pups than sighted ones, likely due to a phenomenon of sensory compensation.

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The parental brain and behavior: A target for endocrine disruption

Cited by 41 publications

References 331 publications

Sublethal exposure to deltamethrin impairs maternal egg care in the European earwig Forficula auricularia

Sublethal exposure to deltamethrin impairs maternal egg care in the European earwig Forficula auricularia

Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior

Enhanced maternal behaviors in a mouse model of congenital blindness

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