The Partition Coefficient of Gd‐DTPA Reflects Maintained Tissue Viability in a Canine Model of Chronic Significant Coronary Stenosis

Abstract

This study is consistent with the hypothesis that lambda is not increased in reversibly dysfunctional myocardium.

Magnetic resonance imaging dynamic contrast enhancement (DCE) characteristics of healed myocardial infarction differ from viable myocardium

“…Measurement of the partition coefficient is theoretically based upon an equilibrium state between blood and myocardial tissue. Initially studies focused on a constant infusion protocol, where a constant blood gadolinium concentration is established through continuous infusion of Gd contrast agent to counterbalance the excretion of Gd contrast from the blood via the kidneys [8,9]. This protocol is time consuming and not well suited to be integrated into clinical practice.…”

“…Interest in a quantitative magnetic resonance (MR) measure to enhance detection and characterization of fibrotic myocardial disease has a long history [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The current challenge is that conventional late gadolinium-enhanced (LGE) techniques cannot reliably be used to detect global or diffuse fibrosis due to the lack of a normal myocardial reference region to detect regional gadolinium contrast agent elevations.…”

“…The current challenge is that conventional late gadolinium-enhanced (LGE) techniques cannot reliably be used to detect global or diffuse fibrosis due to the lack of a normal myocardial reference region to detect regional gadolinium contrast agent elevations. Several quantitative measures have been explored and primarily rely on post-contrast myocardial T1 measurements [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Post-contrast T1 measurements can be used by themselves [20] or in conjunction with a pre-contrast myocardial T1 measurement [21] and hematocrit [4] to provide a quantitative variable related to the tissue contrast agent concentration or distribution volume (V d ) and hence degree of myocardial fibrosis.…”

Multicompartmental analysis of late contrast enhancement in areas of myocardial infarction supplied by chronically occluded coronary arteries

“…As evidenced in Fig. 5, however, the tracer's IDV can be adequately approximated by the partition coefficient that only requires the recording of pre-and postcontrast images from the same slices (18,19).…”

Comparison of the Detection of Subtle Changes in Myocardial Regional Systolic Function Using Qualitative and Semi-Quantitative Techniques

“…It has been previously documented that this model induces small reversible reductions in regional wall motion (18). Hence, these two methods to evaluate perturbations in regional ventricular function are investigated in the setting of expected small, reversible changes.…”