The partitioning and distribution of neonicotinoid insecticides in human blood

Zhang, Quan; Hu, Shitao; Dai, Wei; Gu, Sijia; Ying, Zeteng; Wang, Rui; Lu, Chensheng

doi:10.1016/j.envpol.2023.121082

Cited by 15 publications

(5 citation statements)

References 56 publications

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“…A recent report indicated that neonicotinoid insecticides, including imidacloprid, were detected in human blood. 54 They examined 115 blood samples and interestingly, the neonicotinoid insecticide with the highest detection rate in red blood cells was thiamethoxam, F I G U R E 6 Downregulation of Csf1r expression by developmental exposure to imidacloprid. Imidacloprid (IMI) was administered to dams via drinking water at a dosage of 0.1 mg/kg/day from E11 to P10.…”

Section: Discussionmentioning

confidence: 99%

“…A recent report indicated that neonicotinoid insecticides, including imidacloprid, were detected in human blood 54 . They examined 115 blood samples and interestingly, the neonicotinoid insecticide with the highest detection rate in red blood cells was thiamethoxam, which was found in 19.1% of samples; however, the neonicotinoid with the highest detection rate in plasma was imidacloprid, which was found in 26.1% of samples.…”

Section: Discussionmentioning

confidence: 99%

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Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice

Namba,

Tominaga,

Ishihara

2024

Environmental Toxicology

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Neonicotinoids are insecticides widely used in the world. Although neonicotinoids are believed to be toxic only to insects, their developmental neurotoxicity in mammals is a concern. Therefore, we examined the effects of developmental exposure to neonicotinoids on immune system in the brain and post‐developmental behaviors in this study. Imidacloprid or clothianidin was orally administered to dams at a dosage of 0.1 mg/kg/day from embryonic day 11 to postnatal day 21. Imidacloprid decreased sociability, and both imidacloprid and clothianidin decreased locomotor activity and induced anxiety, depression and abnormal repetitive behaviors after the developmental period. There was no change in the number of neurons in the hippocampus of mice exposed to imidacloprid. However, the number and activity of microglia during development were significantly decreased by imidacloprid exposure. Imidacloprid also induced neural circuit dysfunction in the CA1 and CA3 regions of the hippocampus during the early postnatal period. Exposure to imidacloprid suppressed the expression of csf1r during development. Collectively, these results suggest that developmental exposure to imidacloprid decreases the number and activity of microglia, which can cause neural circuit dysfunction and abnormal behaviors after the developmental period. Care must be taken to avoid exposure to neonicotinoids, especially during development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice

Namba,

Tominaga,

Ishihara

2024

Environmental Toxicology

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“…Multiple studies have measured concentrations of neonicotinoids in human breast milk, blood, saliva, and urine samples. [21][22][23][24] A representative sample from the National Health and Nutrition Examination Survey (NHANES) showed moderate detection frequencies of urinary neonicotinoids, with nearly 50% of the participants having a detectable concentration of at least one neonicotinoid biomarker tested. 25 High detection frequencies (70%) of urinary metabolites of neonicotinoids were also reported among samples collected from rural Iowa, US.…”

Section: Introductionmentioning

confidence: 99%

Associations between neonicotinoids and liver function measures in US adults: National Health and Nutrition Examination Survey 2015–2016

Godbole,

Chen,

Vuong

2024

Environmental Epidemiology

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Background: Toxicological studies indicate that neonicotinoids may be associated with disruptions in liver function due to an increase in oxidative stress. There are scant epidemiological studies investigating the chronic hepatotoxic effects of neonicotinoids. Objective: To examine the association between detectable concentrations of parent neonicotinoids and neonicotinoid metabolites with liver function markers among US adults, and whether sex modifies this association. Methods: National Health and Nutrition Examination Survey 2015–2016 data were used to estimate associations between detectable neonicotinoids and serum alkaline phosphatase (ALP), alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transaminase (GGT), albumin, total bilirubin, total protein, and Hepatic Steatosis Index (HSI) using multiple linear regression. Results: Detectable levels of N-desmethyl-acetamiprid were associated with a decrease in GGT (β = −3.54 unit/l; 95% confidence interval [CI] = −6.48, −0.61) and detectable levels of 5-hydroxy-imidacloprid were associated with a decrease in HSI (β = −1.11; 95% CI = −2.14, −0.07). Sex modified the association between any parent neonicotinoid and ALP (P int = 0.064) and the association between clothianidin and ALP (P int = 0.019), with a pattern of positive associations in males and inverse associations in females, though stratified associations did not reach statistical significance. Sex also modified the association between 5-hydroxy-imidacloprid and total protein (P int = 0.062), with a significant positive association in females (β = 0.14 g/dl; 95% CI = 0.03, 0.25) and a null association in males. Conclusion: Detectable concentrations of neonicotinoid metabolites were inversely associated with GGT and HSI in US adults. Evidence suggests neonicotinoids may influence liver function differently depending on sex. Future research is recommended to replicate the findings as the study was limited in its cross-sectional nature and inability to examine continuous neonicotinoid concentrations with liver function.

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“…Environmental pollutants, especially water-soluble pollutants such as neonicotinoid insecticides and dyes, greatly affects human life and health. [1][2][3] Therefore, the investigation of efficient treatment methods to remove these chemical wastes has been a concern for the majority of researchers for a long time. 4,5 Generally, there are many approaches to cure these pollutant problems, such as physical, chemical and biological processes.…”

Section: Introductionmentioning

confidence: 99%

Hybrid porous polymers based on double‐decker and cage‐ype silsesquioxanes for the high‐efficiency removal of neonicotinoid insecticides and dyes

Zhao

Liu

2023

Journal of Polymer Science

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Different ratios of octavinylsilsesquioxane (OVS) reacted with phenyl‐substituted double‐decker silsesquioxane (Ph‐DDSQ) via the simple Friedel‐Crafts reaction provides several innovative silsesquioxane‐based porous polymers (PCS‐ODs). The hybrid polymers show adjustable porosity (specific surface areas of 1235 m2 g−1 and large pore volumes >1.07 cm3 g−1). FTIR, SEM, BET, TGA, solid‐state 13C and 29Si MAS NMR spectra were employed to fully characterize these hybrid materials. They display good adsorption capacities for neonicotinoid insecticides (imidacloprid [IMI], acetamidine [ACE] and thiamethoxam [THI]), with capacities up to 117 ± 2, 70 ± 1 and 61 ± 4 mg g−1, respectively. Dyes (Congo red [CR] and rhodamine B [RB]) can also be sufficiently removed, the adsorption capacities are 1822 ± 4 and 912 ± 3 mg g−1. In addition, PCS‐ODs can be cycled at least five times.

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The partitioning and distribution of neonicotinoid insecticides in human blood

Cited by 15 publications

References 56 publications

Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice

Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice

Associations between neonicotinoids and liver function measures in US adults: National Health and Nutrition Examination Survey 2015–2016

Hybrid porous polymers based on double‐decker and cage‐ype silsesquioxanes for the high‐efficiency removal of neonicotinoid insecticides and dyes

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