The Pathogenesis and Treatment of Optic Disc Swelling in Neurosarcoidosis

Katz, Jeffrey M.; Bruno, Michiko Kimura; Winterkorn, Jacqueline M.S.; Nealon, Nancy

doi:10.1001/archneur.60.3.426

Cited by 73 publications

(36 citation statements)

References 23 publications

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“…There were no adverse effects associated with infliximab. Our findings are consistent with two recent case reports in which infliximab proved effective for patients with refractory neurosarcoidosis [6,7].…”

supporting

confidence: 93%

Successful treatment of steroid-refractory neurosarcoidosis with infliximab

et al. 2004

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supporting

confidence: 93%

Successful treatment of steroid-refractory neurosarcoidosis with infliximab

et al. 2004

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“…From behavioral neurosciences it is well known that the two cerebral hemispheres behave differently with emotional processing, such as judgment of facial expressions and mood in others [14], found to be disturbed in patients with right mesial TLE [15]. The right hemisphere harbors cognitive functions that are vital for the survival of the species and therefore faster and earlier developed than left-hemispheric functions [16].…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Comorbidity in Patients Evaluated for Chronic Epilepsy: A Differential Role of the Right Hemisphere?

et al. 2009

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Introduction: Psychiatric disorders are known to occur frequently in chronic epilepsy. The aim of this study is to investigate the prevalence of psychiatric comorbidity and its relationship to regional cerebral dysfunction in patients admitted to a tertiary epilepsy center for epilepsy surgery. Methods: 217 patients were investigated. A presurgical workup was performed and allowed precise localization of the epileptogenic focus in 156 patients. Sixty-one patients had multifocal or generalized discharges. After 1–3 psychiatric interviews, a psychiatric diagnosis was made (DSM-IV classification). Results: Psychiatric comorbidity was found in 85 patients (39%), more often in those with right or bilateral hemispheric dysfunction (74%, p = 0.04) with no difference between temporal or extratemporal foci location frequency. Additionally, patients with psychiatric disorders were less likely to undergo epilepsy surgery compared to ‘epilepsy-only’ patients (p = 0.003), despite similar good outcome in patients with and without psychiatric comorbidity. Conclusions: Right-sided or bilateral foci seem to represent a risk factor for psychiatric comorbidity in epilepsy, although we did not find any particular association between a psychiatric syndrome and focus localization. Recognition and treatment of psychiatric comorbidity is of major importance since its presence may interfere with patient’s decision making for epilepsy surgery treatment.

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“…Repeated infusions may also prevent ocular relapses and maintain visual acuity [16][17][18]. Beneficial preliminary results following systemic administration of infliximab have been reported in patients with refractory ocular sarcoidosis [19,20], neurosarcoidosis with optic disk swelling [21], chronic ocular inflammationassociated refractory cystoid macular edema [22] and diabetic macular edema [23]. Regression of experimentallyinduced choroidal neovascularization after treatment with anti-TNF agents has been demonstrated in animal models [24,25], >as well as in patients with choroidal neovascularization secondary to age-related macular regeneration [26].…”

Section: Introductionmentioning

confidence: 99%