The pathogenesis of acute, latent and recurrent herpes simplex virus infections

Klein, Richard J.T.

doi:10.1007/bf01348961

Cited by 72 publications

(26 citation statements)

References 104 publications

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“…In contrast, in patients with recurrent herpes labialis the specific IgG and IgA antibodies were not found to fluctuate significantly during the course of infection (Fig.1). These results are in agreement with previous studies that have shown that serum HSV neutralizing antibodies may fluctuate after primary infection but remain usually high and constant after recurrent infection [Docherty and Chopan, 1974;Shore and Nahmias, 1982;Klein, 1982;Sarov, 19841. A significant rise of HSV IgG antibodies was seen, however, in some cases of HSV encephalitis and in severe cases of recurrent mucocutaneous lesions [Kalimo et al, 19771.…”

Section: Discussionsupporting

confidence: 95%

Specific IgG and IgA antibodies to herpes simplex virus (HSV)‐lnduced surface antigen in patients with HSV infections and in healthy adults

Hadar

Sarov

1984

Journal of Medical Virology

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Herpes simplex virus (HSV)-specific IgG and IgA antibody response in patients with HSV infection and in healthy adults was studied by the immunoperoxidase antibody-membrane antigen (IPAMA) technique. In all HSV infections in which specific IgM antibodies were detected by enzyme-linked immunosorbent assay (ELISA), a significant rise in the titer of HSV IgG and IgA antibodies was found. In contrast, in patients with recurrent herpes labialis in which no specific HSV IgM antibodies were detected by ELISA, HSV IgG and IgA antibodies were not found to fluctuate significantly during the course of infection. A higher geometric mean titer (GMT) for HSV IgG and for IgA antibodies was found in seropositive individuals with a previous history of recurrent HSV than in seropositive individuals without a previous history of recurrent HSV infection. Nineteen of 26 HSV IgG seropositive healthy medical students without a previous history of recurrent HSV infection had HSV IgA antibodies to membrane antigen. The significance of this finding in understanding the mechanism of latency in healthy seropositive individuals without previous history of HSV recurrent infections is discussed.

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Section: Discussionsupporting

confidence: 95%

Specific IgG and IgA antibodies to herpes simplex virus (HSV)‐lnduced surface antigen in patients with HSV infections and in healthy adults

Hadar

Sarov

1984

Journal of Medical Virology

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“…Studies on the spread of virus in experimental animals have emphasized the importance of the retrograde axonal flow of sensory nerves in transfer of the infection to ganglia and the CNS (for reviews, see Klein, 1982;Johnson, 1982). The HSV infection is transferred from neuron to neuron by neuritic extensions of dissociated neuronal cells cultured in vitro and this transfer is inaccessible to antibodies (Price et al,t982).…”

Section: Discussionmentioning

confidence: 99%

Uptake and Transport of Herpes Simplex Virus in Neurites of Rat Dorsal Root Ganglia Cells in Culture

Lycke

Kristensson

Svennerholm

et al. 1984

Journal of General Virology

127

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SUMMARYAttachment and neuritic transport of herpes simplex virus (HSV) type 1 (McIntyre) were studied in a cell culture system with dissociated cells of rat dorsal root ganglia. The two-chamber cell culture system containing a diffusion barrier penetrated by neurites of cultured sensory neurons permitted infection of neurites extending outside the diffusion barrier without exposure of the neuronal cell soma. HSV adsorbed to neuritic extensions and reached the neuronal soma within 1.5 h post-inoculation. Neuritic uptake and transport of HSV were inhibited in the presence of cytochalasin B. Internalization of virus in neurites was preceded by attachment of virus to the neurite plasma membrane. Neurites transported viral nucleocapsids (NC) through the diffusion barrier of the cultures. Destruction of the neuritic extensions before or shortly after peripheral virus inoculation blocked spread of infection to the cell soma. No infection was established when neuritic extensions were exposed to viral NC and NC were then not observed inside the neurite plasma membrane. Virus produced in neurons, when HSV was inoculated into the inner culture chamber containing the neuronal cell bodies, was transported as enveloped virus in cytoplasmic vesicles from the neuronal cell body towards the periphery. Schwann cells were infected by viropexis. Shortly after infection virions were observed in vacuoles of the cytoplasm.

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“…Although treatment with acyloguanosine (acyclovir) can ameliorate recurrent infection (van Landingham et al, 1988), eradication of an established latent infection using this drug has not been successful (Klein, 1982). Although existing experimental HSV vaccines are also ineffective in eliminating latent virus in both animals and man, subunit vaccines composed of HSV glycoproteins can protect against both primary and spontaneous recurrences in guineapigs (Stanberry et al, 1987) and may provide protection against the acquisition of herpes genitalis in man (Skinner et al, 1987).…”

mentioning

confidence: 99%

Antibody Responses and Protection in Mice Immunized with Herpes Simplex Virus Type 1 Antigen Immune-stimulating Complex Preparations

Ertürk

Jennings

Hockley

et al. 1989

Journal of General Virology

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SUMMARYThe formation of immune-stimulating complexes (iscoms) obtained by mixing the glycoside Quil A with an antigen preparation derived from herpes simplex virus type l (HSV-1)-infected cell cultures using a zwitterionic detergent is described. The HSV-I antigen preparation incorporated into iscoms elicited significantly greater antibody responses in mice than the same preparation administered together with aluminium hydroxide gel, and provided complete protection against HSV-1 or HSV-2 lethal, systemic challenge infection in animals given a single dose containing 5 ~tg of protein.The HSV-1 iscom preparation also provided significant protection in mice against local reactions following challenge with HSV-1 by skin scarification.

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The pathogenesis of acute, latent and recurrent herpes simplex virus infections

Cited by 72 publications

References 104 publications

Specific IgG and IgA antibodies to herpes simplex virus (HSV)‐lnduced surface antigen in patients with HSV infections and in healthy adults

Specific IgG and IgA antibodies to herpes simplex virus (HSV)‐lnduced surface antigen in patients with HSV infections and in healthy adults

Uptake and Transport of Herpes Simplex Virus in Neurites of Rat Dorsal Root Ganglia Cells in Culture

Antibody Responses and Protection in Mice Immunized with Herpes Simplex Virus Type 1 Antigen Immune-stimulating Complex Preparations

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