The Pathogenetic Concept of the Diagnostic-Treatment Approach for Patients with Purulent-Septic Complications

Ostapiuk, Lesia

doi:10.4236/ijcm.2022.131001

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Purulent-Inflammatory Diseases and Sepsis Over the past twenty years, some authors [10] [11] have demonstrated the diag-nostic value of MFS, which was illustrated specifically on the disease models "in vitro" [12], as well as specifically "in vivo" and confirmed in clinical practice for patients with obstetric [13] and surgical [14] pathologies and with burn injury [15] [16]. Considerable attention was paid to the understanding of the essence of the pathological processes that occur in the bodies of patients with purulentseptic diseases at the molecular level.…”

Section: The Modified Diagnostic and Treatment Model Ofmentioning

confidence: 99%

Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The Modified Pathogenetic Concept

Kovalenko¹,

Ostapiuk²,

Voloshinovskii³

2023

IJCM

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Background: The deep understanding of pathogenesis is a key moment in the formation of the modern strategy of modern medicine. We conducted the thorough analysis of the microscopic processes occurring in the bodies of patients with purulent-septic complications. The modified pathogenetic concept of the diagnostic and treatment model of diseases with septic complications is presented. The obtained information about the mechanisms of origin and development of these diseases is fundamentally important for finding the modern effective methods of treating patients. The aim of the research is to modify treatment tactics for patients with sepsis and burn injuries based on How to cite this paper: Kovalenko, O., Ostapiuk, L. and Voloshinovskii, A. (2023) Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The

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Section: The Modified Diagnostic and Treatment Model Ofmentioning

confidence: 99%

Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The Modified Pathogenetic Concept

Kovalenko¹,

Ostapiuk²,

Voloshinovskii³

2023

IJCM

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“…They describe the corresponding characteristics for normal (I Three main scenarios for the development of sepsis have been identified and described [6,7,10]. We will dwell on two of them in more detail.…”

Section: Scientific Trends and Trends In The Context Of Globalization...mentioning

confidence: 99%

Current Problems of the Diagnostics and Treatment of Purulent-Inflammatory Diseases and Sepsis

Kovalenko

Ostapiuk²

2022

InterConf+

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A deep understanding of the pathogenesis is the key point in the formation of diagnostic strategies and treatment tactics for patients with various diseases. In this paper, the thorough analysis of the microscopic processes that occur in the bodies of patients with purulent-septic diseases was carried out. The pathogenetic concept of the diagnostic and treatment model of purulent-inflammatory diseases and sepsis was proposed and presented. It is based on the fact that in diseases accompanied by endogenous intoxication, part of the albumin molecules in the blood of patients are blocked by toxins. However, the presence of albumin in the blood does not always reflect the completeness of its transport function. Its binding centers can be blocked by toxic ligands, due to which the transport capacity is sharply reduced. As a result, there are two types of albumin molecules in the blood: normal (concentration: X) and blocked by toxins /pathological (concentration: 1-X). So, pathological albumin molecules lose the ability to perform their basic functions, namely transport and detoxification. This allows us to assume that the presence of albumin and its functional state can influence the course of burn disease and the development of sepsis. The proposed diagnosis of sepsis consists in definition of Х*, i.e. the maximum minimum value of the concentration of albumin in patients with sepsis. If Х is more than Х*, this ensures the viability of the organism to some extent. Modern complex diagnostics, including early, within the framework of the method of fluorescence spectroscopy and biomarkers of purulent-septic diseases, and effective methods of their treatment and modern effective control of the treatment process are proposed.

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“…Statistics from European countries and the United States shows that the annual incidence of salpingitis and oophoritis is 12-14 cases per 1000 women [3], while 5-15% of women are diagnosed with purulent inflammatory diseases of the fallopian tubes and ovaries [4]. Inflammatory processes affecting the internal genital organs lead to a decrease in the reproductive potential of women, provoking the development of chronic pelvic pain, miscarriage, infertility and ectopic pregnancy [5]. The most prognostically unfavorable inflammatory disease for female fertility is pelvioperitonitis -one of the most urgent problems of gynecology, which accounts for about 30% of the total number of patients in a gynecological hospital.…”

Section: Introductionmentioning

confidence: 99%

Experience of Using Enhanced Postoperative Recovery Program in the Treatment of Pelvioperitonitis

Сулима¹,

Рыбалка²,

Mykhaylichenko³

et al. 2023

ArveMED

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Purpose: This article describes the experience of using the Enhanced Recovery After Surgery (ERAS) program in the treatment of female patients with pelvioperitonitis in a gynecological in-patient department. Materials and Methods: We examined 60 female patients who were divided into the main and comparison groups. The groups were comparable in terms of age, marital status, education, and place of residence. In addition to the standard approaches in the treatment of pelvioperitonitis, 30 patients of the main group were treated using some elements of the concept of enhanced recovery, such as detailed preoperative counseling about future treatment, non-use of premedication, control of hypothermia during and after surgery, prevention of dyspeptic disorders in postoperative period, avoiding narcotic analgesics, early enteral nutrition and mobilization. In the comparison group, which also included 30 patients, the treatment of pelvioperitonitis was carried out in strict accordance with the standard scheme - surgery, balanced infusion therapy, symptomatic treatment. Results: At the same time, the pain level by the visual analogue scale (VAS) averaged 6.11 ± 0.34 after 2, 4 and 8 hours in women from the comparison group. Vomiting was registered in 3 (10.0%) patients from the main group on the day 1 of the postoperative period. Whereas 7 (23.3%) patients from the comparison group had vomiting on the day 1 of the postoperative period. The absence of active motility and passage of flatus, an increase in hypoproteinemia, hypoalbuminemia, and an increase in the level of leukocytosis in both groups showed the severity of the systemic inflammatory response. However, by the end of the day 2 of the postoperative period, the improvement in biochemical parameters was registered as a sign of a positive change in the patients’ general condition. LII decreased by 1.5 times by the day 5 in the comparison group; but in the main group it decreased by 2.3 times. First active peristaltic noises were auscultated and first passage of flatus were noted on average after 20.33 ± 1.02 hours in the main group, but in the comparison group - after 40.28 ± 0.81 hours. In addition to that, the need for pharmacological intestinal stimulation was 2.5 times higher in patients from the comparison group than in patients from the main group. Postoperative purulent inflammation of the wound was registered in 9 (30.0%) women from the control group. However, only 2 (6.7%) women from the main group had one of the above mentioned disorders. The absolute risk reduction is 15% and NNT = 7. The average hospital stay for patients from the main group was 6.15 ± 0.25 days, and 8.64 ± 0.38 days for women from the comparison group. Conclusion: The results obtained during the study prove the effectiveness of the concept of enhanced recovery in the treatment of pelvioperitonitis.

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The Pathogenetic Concept of the Diagnostic-Treatment Approach for Patients with Purulent-Septic Complications

Cited by 5 publications

References 16 publications

Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The Modified Pathogenetic Concept

Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The Modified Pathogenetic Concept

Current Problems of the Diagnostics and Treatment of Purulent-Inflammatory Diseases and Sepsis

Experience of Using Enhanced Postoperative Recovery Program in the Treatment of Pelvioperitonitis

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