The Pathologic Picture as Revealed at Autopsy in a Series of 61 Fatal Cases Treated at the Hospital for Sick Children, Toronto, Canada

Erb, I. H.; Morgan, Ethel M.; Farmer, A. W.

doi:10.1097/00000658-194302000-00010

Cited by 37 publications

(11 citation statements)

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“…The mechanism of oliguria or anuria as related to the histology of the kidney in these conditions is a debated subject. 44,48,49 The immediate treatment of a severely burned patient, however, should probably include the administration of fluids and alkali in an attempt to establish prompt diuresis of neutral or alkaline urine.…”

Section: Discussionmentioning

confidence: 99%

Studies on the Destruction of Red Blood Cells

et al. 1943

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Section: Discussionmentioning

confidence: 99%

Studies on the Destruction of Red Blood Cells

et al. 1943

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“…From 1925 to 1942, tannic acid was widely use topically for the treatment of severely burnt skin. While this was found to be an effective treatment, it was realized that it also caused necrosis of the liver (Erb et al ., 1943), and the practice was therefore discontinued. Tannic acid has also been used for diagnostic purposes.…”

Section: (Iv) Effects Of Tannins On Animalsmentioning

confidence: 99%

Interaction of Plant Polyphenols with Salivary Proteins

Bennick

2002

Critical Reviews in Oral Biology & Medicine

385

265

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Tannins are polyphenols that occur widespread in plant-based food. They are considered to be part of the plant defense system against environmental stressors. Tannins have a number of effects on animals, including growth-rate depression and inhibition of digestive enzymes. Tannins also have an effect on humans: They are, for example, the cause of byssinosis, a condition that is due to exposure to airborne tannin. Their biological effect is related to the great efficiency by which tannins precipitate proteins, an interaction that occurs by hydrophobic forces and hydrogen bonding. Two groups of salivary proteins, proline-rich proteins and histatins, are highly effective precipitators of tannin, and there is evidence that at least proline-rich proteins act as a first line of defense against tannins, perhaps by precipitating tannins in food and preventing their absorption from the alimentary canal. Proline plays an important role in the interaction of proline-rich proteins with tannins. In contrast, it is primarily basic residues that are responsible for the binding of histatins to tannin. The high concentration of tannin-binding proteins in human saliva may be related to the fruit and vegetable diet of human ancestors.

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“…The histological pictures associated with acute renal failure following abortion, incompatible blood transfusion, crush injuries, severe trauma, blackwater fever, sulphonamide intoxication, and many other conditions including burns have been described by various writers (Bratton, 1941 ;Dunn, Gillespie, and Niven, 1941;Bywaters and Beall, 1941;Bywaters and Dible, 1942;Erb, Morgan, and Farmer, 1943;Shen, Ham, and Fleming, 1943;Lucke, 1946;Goodpastor, Levenson, Tagnon, Lund, and Taylor, 1946;Oliver, Mac-Dowell, and Tracy, 1951;Oliver, 1953;Bull and Dible, 1953). Lucke, whose report included 48 fatally burned subjects, claimed that there was a common morphological picture for acute renal failure caused by a variety of conditions.…”

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confidence: 99%