The pathology of adult type Letterer-Siwe disease

Langerhans'cell tumor of the eyelid

“…In this age group, the lesions are eom- parable to those of Letterer-Siwe disease of childhood in distribution and form (Vollum 1 979). The histopalhology of the cutaneous lesion is also .similar (Wells 1979).…”

“…1967). However, Wells (1979) suggested that the skin may be an important repository of tvimor cells and that skin lesions should be adequately treated. Sajjad and Osborne (1982) reported that lymph-node involvement is usually secondary to skin or bone lesions in the vicinity.…”

Aggressive histiocytic disorders that can involve the skin

“…In LetterereSiwe disease, the infiltrate is composed largely of LCs with scattered lymphocytes, eosinophils, and occasional neutrophils (Fig 1, B and C ). 20 In Hand-Schuller-Christian disease, there is a prominent granulomatous reaction (made up of aggregates of histiocytes) and, rarely, cells with xanthomatous changes. 21 In eosinophilic granuloma and Hand-Schuller-Christian disease, clusters of eosinophils are prominent and there are occasional multinucleate giant cells.…”

Cutaneous Hematopathology

“…Eosinophils are scattered throughout the infi ltrate and the epidermis is free of infi ltrating cells (Hashimoto and Pritzker 1973 ). Letterer-Siwe disease has infi ltrates that are composed largely of LCs with scattered lymphocytes, eosinophils, and occasional neutrophils (Wells 1979 ). In Hand-Schuller-Christian disease, there is a prominent granulomatous reaction made of aggregates of histiocytes and rarely cells with xanthomatous changes (Altman and Winkelmann 1963 ).…”