The Pathology of Experimental Roentgen-Cystitis in Dogs

Hueper, W. C.; Fisher, Christine; Carvajal-Forero, J. de; Thompson, Marvin R.

doi:10.1016/s0022-5347(17)70782-3

Cited by 14 publications

(6 citation statements)

References 9 publications

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“…Anronakopoulos et a/. (1) described a marked collagen deposition in the muscular layers at 6 months after irradiation with a continuous destruction of the muscle cells, but as in previous publications (10,16) the results are descriptive and qualitative rather than quantitative.…”

Section: Discussionmentioning

confidence: 78%

“…Previous reports on histological changes in the bladder after irradiation have been descriptive (1,10,16), with no attempt to perform a quantitative estimation of the amount of different tissue components with special reference to late normal bladder tissue damage. This implies that no estimation of the total tissue volume was included and therefore any difference in the relative amount of tissue was not discussed in relation to the actual volume of tissue examined.…”

Section: Discussionmentioning

confidence: 99%

“…Vascular changes are considered to be an important feature in the development of late radiation damage (1,9,10,16). In this study only a hint of a decreased number of vessels/capillaries was noticed in the 20 Gy group, whilst no statistically significant changes were detected (0.1 > p > 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…The bladder was irradiated with X-rays generated with a 250 kV constant potential; the irradiation pro-cedure and dosimetry have been described previously (21). The irradiation was given as single fractions in a range of doses (10-25 Gy X-rays alone, or [10][11][12][13][14][15] Gy in combination with chemotherapy). Cyclophosphamide (CTX) and cis-diamminedichloroplatinum (11) (cis-DDP) were given intraperitoneally 45 min prior to irradiation at doses of 100 mgikg and 6 mg/ kg, respectively.…”

Section: Irradiation and Drug Treatmentmentioning

confidence: 99%

“…Other studies have described histological changes in tissues with time after irradiation alone or combined with chemotherapy (1,9,10,16,18,21), or have investigated cell kinetic perturbations in the irradiated tissues (4,5,20). Whereas cell kinetic studies are strictly quantitative, the investigations based on histological changes are mainly qualitative or at best semiquantitative.…”

mentioning

confidence: 99%

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Late changes in the normal mouse bladder after irradiation alone or in combination with cis‐DDP or cyclophosphamide, assessed by stereological analysis

Lundbeck

Nielsen

Stewart

1993

APMIS

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Stereological analysis has been performed to investigate the late changes in the normal mouse bladder one year after radiation alone (10–25 Gy) or radiation (10–15 Gy) combined with cyclophosphamide (CTX), 100 mg/kg, or cis‐diamminedichloroplatinum (II) (cis‐DDP), 6 mg/kg. A significant increase in total volume of urothelium was found in the group treated with CTX combined with radiation compared with the control. The total volume of connective tissue in the muscular layer in the groups which received X‐rays only showed a significant increase compared to the control. There also seemed to be an increase in the amount of connective tissue in muscular tissue, although this was not statistically significant, in the groups treated with CTX and irradiation compared with CTX alone. This indicates the importance of radiation in the development of late damage. Results from bladders treated with cis‐DDP alone or combined with radiation were statistically inconclusive due to the small number of animals in each group. The group treated with CTX and radiation (15 Gy) showed a significant decrease in the total volume of lamina propria, but no difference was found in the other treatment groups when comparing connective tissue, the muscular layer or the amount of vessels and capillaries with their corresponding control groups. Stereological analysis seems a feasible method to demonstrate late bladder tissue changes encountered after irradiation alone or combined with chemotherapy.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%