In the matrix of relations between the physiology, anatomy, and behavior of the older nervous system, a particular vantage point is research on the-slowness of behavior with age. A review of the evidence indicates that the slowing of behavior with age not only appears in motor responses and sensory processes but becomes more obvious with increasing complexity of behavior. For this reason the expression "slowness of behavior with age" is preferred to the more limited phrase "changes in reaction time with age." While there are probably both general and specific factors in behavioral slowing with age, the organization of a general factor of slowness raises some fundamental questions. Behavioral factors are apparently involved, but more recent emphasis has been placed on the role of neurobiological changes in the central nervous system.

This article provides individualized risk estimates based on large numbers for patients with HL undergoing follow-up after radiotherapy at young ages. Follow-up of such women needs to continue for 40 years or longer and may require more-intensive screening regimens than those in national general population programs. Special consideration is needed of potential measures to reduce breast cancer risk for girls treated with supradiaphragmatic radiotherapy at pubertal ages.

There have been only two relapses among 114 cases of high-risk stage I NSGCTT treated with two courses of adjuvant BEP chemotherapy. The 95% confidence interval (CI) excludes a true relapse rate of more than 5%. Of 104 patients confirmed on histopathology review to have GCT, there has been only one relapse. Adjuvant chemotherapy is free from significant long-term toxicity, offering an effective alternative to surveillance or retroperitoneal lymph node dissection (RPLND) followed by surveillance, and may be preferred by some patients.

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