The pathology of the end-stage osteoarthritic lesion of the knee: Potential role in cartilage repair

Johnson, Laverne C.; Verioti, Christopher A; Gelber, Jonathan; Spector, Myron; D’Lima, Darryl D.; Pittsley, Andrew

doi:10.1016/j.knee.2010.07.012

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…These facts illustrate the need for new and effective treatments for these injuries 4, 5 . Currently, intensive research efforts have produced a considerable amount of basic science knowledge for cruciate ligament 6–8 , meniscal 9, 10 and cartilage 11, 12 injuries. However, before human patients can benefit from such data, translational work in large animal models is often necessary to comply with regulatory requirements and the principles of translational medicine 13 .…”

Section: Introductionmentioning

confidence: 99%

A comparative anatomical study of the human knee and six animal species

et al. 2012

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Purpose Animal models are an indispensable tool for developing and testing new clinical applications regarding the treatment of acute injuries and chronic diseases of the knee joint. Therefore, the purpose of this study was to compare the anatomy of the intra-articular structures of the human knee to species commonly used in large animal research studies. Methods Fresh frozen cow (n=4), sheep (n=3), goat (n=4), dog (n=4), pig (n=5), rabbit (n=5), and human (n=4) cadaveric knees were used. Passive range of motion and intra-articular structure sizes of the knees were measured, the structure sizes normalized to the tibial plateau, and compared among the species. Results Statistically significant differences in the range of motion and intra-articular structure sizes were found among all the species. Only the human knee was able to attain full extension. After normalization, only the pig ACL was significantly longer than the human counterpart. The tibial insertion site of the ACL was split by the anterior lateral meniscus attachment in the cow, sheep, and pig knees. The sheep PCL had two distinct tibial insertion sites, while all the other knees had only one. Furthermore, only in human knees, both lateral meniscal attachments were located more centrally than the medial meniscal attachments. Conclusions/Clinical Relevance Despite the relatively preserved dimensions of the cruciate ligaments, menisci, and intercondylar notch amongst human and animals, structural differences in the cruciate ligament attachment sites and morphology of the menisci between humans and animals are important to consider when selecting an animal model.

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Section: Introductionmentioning

confidence: 99%

A comparative anatomical study of the human knee and six animal species

et al. 2012

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“…12 There are many factors that are contributing to the success or failure of arthroscopic abrasion arthroplasty. By the age group averages reported, it would seem that the lesions were traumatic in nature and the abrasion was performed instead of microfracture.…”

Section: Microfracturementioning

confidence: 99%

The New Microfracture: All Things Considered

Johnson¹,

Spector²

2015

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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“…Biocompatibility and biodegradability should be pursued with greater efficiency in every material used 1,2 . Biopolymers are obtained through renewable sources of carbon, such as carbohydrates derived from sugar cane (Saccharum officinarum L.), corn, potatoes, wheat or beetroot [6][7][8][9][10][11][12] . While looking for new advances, an extracellular polysaccharide was obtained by fermenting sugar cane molasses using the microorganism Zoogloea sp, which had already been identified in the department of antibiotics at the Federal University of Pernambuco (UFPE).…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

Albuquerque

Aguiar²,

Filho³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To assess the histological response of damaged osteochondral tissue in the femoral condyles of rabbits after repairing the wounds with sugar cane biopolymer gel -compared to the control group. METHODS:The study investigated 16 New Zealand rabbits, at 90, 120 and 180 days after surgery. In all the animals, a lesion of 3.2 mm in diameter and 4 mm deep was induced in each right and left femoral condyle. Each animal has provided both knees, divided into medial and lateral condyle, resulting in 64 samples. 32 knees were divided into two groups: Right knee, medial and lateral condyles, filled with biopolymer; Left knee, medial and lateral condyles, unfilled. The anatomical specimens were removed, and subjected to histological techniques and morphometric and statistical analysis. RESULTS:In all the periods of the group under study an inflammatory reaction mediated by giant cells and mononuclear cells was found, while in the control group there was early healing produced by fibroblasts and few mononuclear cells with statistical significance between groups. CONCLUSION:The biopolymer gel caused an inflammatory reaction mediated by giant cells and mononuclear cells while the control group there was cicatrization mediated by fibroblasts.Key words: Osteogenesis. Cartilage. Histology. Biopolymers. Rabbits.A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

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The pathology of the end-stage osteoarthritic lesion of the knee: Potential role in cartilage repair

Cited by 6 publications

References 21 publications

A comparative anatomical study of the human knee and six animal species

A comparative anatomical study of the human knee and six animal species

The New Microfracture: All Things Considered

A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

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