The pathology of the human notochord

Salisbury, Jonathan R.

doi:10.1002/path.1711710404

Cited by 125 publications

(91 citation statements)

References 13 publications

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“…40 Here, we compare the general population expected mortality, generated by matching each patient with the US expected mortality tables, to generate the expected mortality estimate (E). 33 Then, the observed deaths (D) are divided by the expected mortality (death count) estimate, as demonstrated shown in Equation 1. Equation 2 demonstrates the calculation of the expected death count from grouped data, with (n) representing the number at risk in interval j and w j representing the total censored patients during interval j.…”

Section: Standardized Mortality Ratiomentioning

confidence: 99%

Incidence and relative survival of chordomas

Smoll

Gautschi

Radovanović

et al. 2013

Cancer

168

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BACKGROUND: Chordomas are rare bone tumors arising from remnants of the embryonic notochord. METHODS: Data for this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute to calculate the incidence, relative survival (RS), and standardized mortality ratio (SMR) of patients diagnosed with intracranial and extracranial chordomas and to assess the effects of age and sex on this disease. RESULTS: The overall incidence of extracranial and intracranial chordomas was 8.4 per 10 million population. The median overall survival of patients with chordoma patients was 7.7 years. The median survival was 7.7 years for male patients and 7.8 years for female patients. Younger patients (aged <40 years) survived longer compared with older patients (10-year RS, 68% vs 43%). The estimated age-standardized 5-year, 10-year, and 20-year RS rates was 72%, 48%, and 31%, respectively. The SMR in the overall cohort was 4.6 (95% confidence interval, 4.22-5.0) or 21.0 (95% confidence interval, 16.6-27.2) in young adult patients and 3.0 (95% confidence interval, 2.6-3.4) in elderly patients. CONCLUSIONS: The elderly had a more aggressive form of this disease; and, other than the incidence, sex did not influence outcome in this disease. The study of chordomas presents a good case for the contribution that the SMR can have on measuring the impact of a disease on a population of patients. Although the younger population has better survival rates, the impact (SMR) in the younger age groups is much higher than in older populations.

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Section: Standardized Mortality Ratiomentioning

confidence: 99%

Incidence and relative survival of chordomas

Smoll

Gautschi

Radovanović

et al. 2013

Cancer

168

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“…This process explains why chordomas are located along the axial skeleton (From the sacrum to the sphenoidal clivus). (4) Extra axial localizations remain possible but exceptional so that the presentation of this case was very surprising. The classic histopathological characteristic of chordoma is the presence of physaliphorous cells.…”

Section: Discussionmentioning

confidence: 88%

Chondroid Chordoma of Nasal Septum : A Case Report

Kailas¹,

M²,

Mathri³

2015

jemds

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ABSTRACT:Chordomas are rare neoplasms of presumed notochordal origin that arise along the vertebral axis and show a proclivity for the spheno-occipital and sacral regions. (1,2) Chondroid chordoma is a variant of chordoma, with cartilaginous component. We report a histologically proven case of chondroid chordoma, with an exceptional localization to the nasal septum. Chondroid Chordomas are likely to recur and hence diagnostically important to institute effective treatment.

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“…One, less likely, theory has been that the channels and foramina along the surface of the basiocciput are of vascular origin (emissary canals), while the other, more probable, theory attributes the presence of channels and pits to their being postnatal vestiges of the cephalic end of the notochordal canal (canalis chordae) [2,4]. The event causing this aberrant development occurs early in the fifth gestational week of embryonic life, when the notochord follows a ''sigmoid-like'' caudal-cranial curve that crosses the clivus approximately three times, initially perforating the occipital plate ventrally near the CBM, and then, when directly in contact with the endoderm of the pharynx, follows a rostral trajectory that penetrates the sphenoid plate near the dorsum sellae (Figure 2) [5,6].…”

Section: Discussionmentioning

confidence: 99%

Not the typical Tornwaldt's cyst this time? A nasopharyngeal cyst associated with canalis basilaris medianus

Lohman¹,

Sarıkaya²,

McKinney³

et al. 2011

BJR

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ABSTRACT. We report a patient with a cystic structure in the nasopharynx mimicking a Tornwaldt's cyst, which was felt to represent a different entity owing to the lack of the distinct features of a typical Tornwaldt's cyst. It was associated with a bony cleft in the basiocciput that was considered to be a canalis basilaris medianus (CBM), thought to represent an embryological vestige of the cephalic end of the notochord along its course within the basiocciput.

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The pathology of the human notochord

Cited by 125 publications

References 13 publications

Incidence and relative survival of chordomas

Incidence and relative survival of chordomas

Chondroid Chordoma of Nasal Septum : A Case Report

Not the typical Tornwaldt's cyst this time? A nasopharyngeal cyst associated with canalis basilaris medianus

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