2024
DOI: 10.1186/s13023-024-03105-0
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The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology

Hemmo A.F. Yska,
Marc Engelen,
Marianna Bugiani

Abstract: Although the pathology of X-linked adrenoleukodystrophy (ALD) is well described, it represents the end-stage of neurodegeneration. It is still unclear what cell types are initially involved and what their role is in the disease process. Revisiting the seminal post-mortem studies from the 1970s can generate new hypotheses on pathophysiology. This review describes (histo)pathological changes of the brain and spinal cord in ALD. It aims at integrating older works with current insights and at providing an overarch… Show more

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Cited by 2 publications
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References 84 publications
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