The pathophysiological nature of sarcomeres in trigger points in patients with myofascial pain syndrome: A preliminary study

Jin, Feihong; Guo, Yaqiu; Wang, Zi; Badughaish, Ahmed; Pan, Xin; Zhang, Li; Feng, Qi

doi:10.1002/ejp.1647

Cited by 28 publications

(39 citation statements)

References 45 publications

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“…The procedure used to recruit MPS patients (M group) and healthy controls (C group) was described in previous publications. 13 Patients with MTrPs were recruited for the study at the orthopaedics department of Qilu Hospital at Shandong University, Jinan, China. Eleven participants were recruited into the M group.…”

Section: Methodsmentioning

confidence: 99%

“…A detailed description of the sample biopsy procedure is provided in our previous publication. 13 Briefly, biopsies from the MTrPs were obtained using a disposable SuperCoreTM Biopsy instrument (ARGON) according to the international consensus on diagnostic criteria established in 2017. 5 The tissues were rapidly frozen in liquid nitrogen and stored at -80 C. The expression of proteins was measured using the RayBio Human Phosphorylation Array Kit (catalogue no.…”

Section: Sample Collection and Proteomic Analysismentioning

confidence: 99%

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Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain

Jin

Zhao

et al. 2020

Mol Pain

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Background Myofascial pain syndrome (MPS) is an important clinical condition that is characterized by chronic muscle pain and a myofascial trigger point (MTrP) located in a taut band (TB). Previous studies showed that EphrinB1 was involved in the regulation of pathological pain via EphB1 signalling, but whether EphrinB1-EphB1 plays a role in MTrP is not clear. Methods The present study analysed the levels of p-EphB1/p-EphB2/p-EphB3 in biopsies of MTrPs in the trapezius muscle of 11 MPS patients and seven healthy controls using a protein microarray kit. EphrinB1-Fc was injected intramuscularly to detect EphrinB1s/EphB1s signalling in peripheral sensitization. We applied a blunt strike to the left gastrocnemius muscles (GM) and eccentric exercise for 8 weeks with 4 weeks of recovery to analyse the function of EphrinB1/EphB1 in the muscle pain model. Results P-EphB1, p-EphB2, and p-EphB3 expression was highly increased in human muscles with MTrPs compared to healthy muscle. EphB1 (r = 0.723, n = 11, P < 0.05), EphB2 (r = 0.610, n = 11, P < 0.05), and EphB3 levels (r = 0.670, n = 11, P < 0.05) in the MPS group were significantly correlated with the numerical rating scale (NRS) in the MTrPs. Intramuscular injection of EphrinB1-Fc produces hyperalgesia, which can be partially prevented by pre-treatment with EphB1-Fc. The p-EphB1 contents in MTrPs of MPS animals were significantly higher than that among control animals (P < 0.01). Intramuscular administration of the EphB1 inhibitor EphB1-Fr significantly suppressed mechanical hyperalgesia. Conclusions The present study showed that the increased expression of p-EphB1/p-EphB2/p-EphB3 was related to MTrPs in patients with MPS. This report is the first study to examine the function of EphrinB1-EphB1 signalling in primary muscle afferent neurons in MPS patients and a rat animal model. This pathway may be one of the most important and promising targets for MPS.

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Section: Methodsmentioning

confidence: 99%

Section: Sample Collection and Proteomic Analysismentioning

confidence: 99%

Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain

Jin

Zhao

et al. 2020

Mol Pain

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“…The substances can sometimes spread to adjacent spinal cord segments and cause referred pain characterized by MTrPs[ 17 ]. The central pain sensitization can increase the excitability of neurons and the expansion of the neuronal receptive fields causing refractory referred pain[ 18 ]. Alternatively, Stecco et al [ 19 ] suggested that muscular fascia, a form of connective tissue, may undergo pathological change under overload and damage leading to the biomechanical change of muscles and eventually to the reduction of contraction force and flexibility of muscles[ 20 ].…”

Section: Pathogenesismentioning

confidence: 99%

Expert consensus on the diagnosis and treatment of myofascial pain syndrome

Cao¹,

Peng²,

Wang³

et al. 2021

WJCC

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Myofascial pain syndrome (MPS) is characterized by myofascial trigger points and fascial constrictions. At present, domestic and foreign scholars have not reached a consensus on the etiology and pathogenesis of MPS. Due to the lack of specific laboratory indicators and imaging evidence, there is no unified diagnostic criteria for MPS, making it easy to confuse with other diseases. The Chinese Association for the Study of Pain organized domestic experts to formulate this Chinese Pain Specialist Consensus on the diagnosis and treatment of MPS. This article reviews relevant domestic and foreign literature on the definition, epidemiology, pathogenesis, clinical manifestation, diagnostic criteria and treatments of MPS. The consensus is intended to normalize the diagnosis and treatment of MPS and be used by first-line doctors, including pain physicians to manage patients with MPS.

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“…В последнее время получила развитие теория, предполагающая наличие положительной обратной связи поддержания МТТ на молекулярном уровне по причине дизрегуляции специфических белков [24]. В настоящее время известно, что тирозин-киназный рецептор (receptor tyrosine kinases, RTK) и Rho-киназы участвуют в процессе Ca 2+ -чувствительного мышечного сокращения.…”

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“…С помощью секвенирования и РНК-анализа в области МТТ подтверждена дизрегуляция данного сигнального пути, обеспечивающего мышечное сокращение. Оказалось, что по сравнению с контрольной группой наблюдается значительное нарушение регуляции 15 белков из семейства RTK в виде увеличения активности, а также снижения функции двух белков из семейства RTK, сопровождающееся частичным повышением экспрессии EphB1/EphB2 на мембранах мышечных клеток, в которых присутствуют аномально сокращенные саркомеры [24].…”

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Contemporary views of the mechanisms for development of myofascial pain syndrome and its treatment strategies

Tabeeva

Kiryanova

2020

RJTAO

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Myofascial pain syndrome (MFPS) is a regional pain syndrome that can be diagnosed in any age group and is characterized by the presence of a trigger point in the muscle involved in the pathological process. Clarifying the molecular mechanisms of trigger point formation and dysregulation of specific skeletal muscle proteins is important to understand the causes of abnormal sarcomere contraction observed in myofascial pain. Wide variability in using the diagnostic criteria in some cases leads to the impossibility of performing a meta-analysis of the data; in this connection, the search for the gold standard for MFPS diagnosis is actively underway. At the moment, a special clinical examination is of paramount diagnostic value. The paper considers various treatment options for myofascial pain and discusses the priority importance of using nonsteroidal anti-inflammatory drugs and muscle relaxants, as well as non-drug therapies.

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The pathophysiological nature of sarcomeres in trigger points in patients with myofascial pain syndrome: A preliminary study

Cited by 28 publications

References 45 publications

Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain

Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain

Expert consensus on the diagnosis and treatment of myofascial pain syndrome

Contemporary views of the mechanisms for development of myofascial pain syndrome and its treatment strategies

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