The Pathophysiology of Inhalation Injury

Enkhbaatar, Perenlei; Sousse, Linda E.; Cox, Robert A.; Herndon, David N.

doi:10.1016/b978-0-323-47661-4.00016-2

Cited by 12 publications

(2 citation statements)

References 143 publications

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“…Ambos gases causan hipoxia tisular, pero por mecanismos diferentes. El monóxido de carbono (CO) se une con 240 veces más afinidad a la hemoglobina (Hb) que el oxígeno [5]. Esto causa un desplazamiento hacia la izquierda en la curva de disociación de la hemoglobina, disminuyendo la entrega de oxígeno a los tejidos, además el CO también tiene capacidad de unión a los citocromos intracelulares causando la desarticulación de los sistemas de respiración celular.…”

Section: Discussionunclassified

Quemaduras severas asociadas a lesión por inhalación

2022

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La lesión por inhalación es uno de los factores de riesgo que más contribuye a la mortalidad de pacientes quemados. La mortalidad asociada a la inhalación de humo es de 48 al 76%, se ha determinado que la mortalidad asociada con las quemaduras aumenta aproximadamente en 20% al combinarse con lesión por inhalación. En Panamá, específicamente en el Hospital del Niño Doctor José Renán Esquivel (HDNJRE), en los últimos 20 años han ocurrido 181 lesiones por inhalación, con una mortalidad asociada del 1.1%. Por esto la importancia de la detección temprana y manejo agresivo de esta patología. Presentamos el caso clínico de un paciente de 9 años quien sufre quemadura térmica por gasolina de un 25.5% y lesión por inhalación referido a nuestra unidad.

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Section: Discussionunclassified

Quemaduras severas asociadas a lesión por inhalación

2022

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“…Transvascular fluid shift is promoted by increased microvascular pressure and permeability to proteins (14). The pro-coagulant state associated with SII leads to massive alveolar fibrin deposition and subsequent worsening of V/Q mismatch (16). Additionally, fibrin deposition directly inhibits surfactant production, which exacerbates pulmonary atelectasis due to increased surface tension within the alveolar sacs (17).…”

Section: Lung Parenchyma Injurymentioning

confidence: 99%

Obstructive Tracheal Necrosis in a Dog Secondary to Smoke Inhalation Injury—Case Report

et al. 2020

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A 4-year-old Siberian Husky mix was referred to the emergency service of the University of California Davis Veterinary Medical Teaching Hospital after being found unconscious in a housefire. Upon arrival, the dog was conscious and panting with normal breathing effort. The dog was initially treated with oxygen therapy to minimize the risk of carbon monoxide toxicosis. Progressive agitation with paroxysmal episodes of increased respiratory effort and increased upper airway sounds were noted ∼48 h after presentation. Hypoxemia was then documented. Clinical signs continued to progress despite supportive measures, and five days after initial presentation mechanical ventilation was deemed indicated. Following anesthetic induction, endotracheal intubation was performed. Capnography and peak inspiratory pressures recorded on the mechanical ventilator were consistent with airway obstruction. Diffuse intraluminal tracheal obstruction with grossly necrotic tracheal tissue was confirmed using fiber optic tracheoscopy. The patient was humanely euthanized due to grave prognosis. At necropsy, the tracheal lumen was obstructed by sloughed, necrotic tracheal mucosa. This is the first report describing a severe delayed intrathoracic large airway complication secondary to smoke inhalation in a dog.

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Burns, Inhalational Injury, and Lightning Injury

Swann¹,

Mohr²

2022

Surgical Critical Care and Emergency Surgery

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The Pathophysiology of Inhalation Injury

Cited by 12 publications

References 143 publications

Quemaduras severas asociadas a lesión por inhalación

Quemaduras severas asociadas a lesión por inhalación

Obstructive Tracheal Necrosis in a Dog Secondary to Smoke Inhalation Injury—Case Report

Burns, Inhalational Injury, and Lightning Injury

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