The Pattern of Glomerular Map Formation Defines Responsiveness to Aversive Odorants in Mice

Cho, Jin Hyung; Prince, Janet E. A.; Cutforth, Tyler; Cloutier, Jean-François

doi:10.1523/jneurosci.2460-10.2011

Cited by 34 publications

(50 citation statements)

References 35 publications

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“…Although the spatial arrangement of glomeruli within the OB contributes to the coding of odor information (Cho et al, 2011;Johnson and Leon, 2007;Mori et al, 2006), it remains unclear whether the formation of glomerular maps in the AOB is essential to mediate stereotypic behaviors regulated by the accessory olfactory system. In the main olfactory system, relatively simple glomerular maps are formed with OSNs expressing the same OR coalescing into an average of two conserved glomeruli per OB.…”

Section: Aob Glomerular Map and The Control Of Pheromonal Responsesmentioning

confidence: 99%

“…Olfactory sensory neuron (OSN) axons expressing a specific olfactory receptor (OR) innervate on average two spatially conserved glomeruli, containing dendrites of second-order neurons, out of the ~1800 glomeruli present in the olfactory bulb (Malnic et al, 1999;Mombaerts et al, 1996;Ressler et al, 1994;Serizawa et al, 2003;Vassar et al, 1994). The spatial arrangement of these glomeruli contributes to the coding of odor information (Cho et al, 2011;Johnson and Leon, 2007;Mori et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression

et al. 2013

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SUMMARYThe accessory olfactory system controls social and sexual interactions in mice that are crucial for survival. Vomeronasal sensory neurons (VSNs) form synapses with dendrites of second order neurons in glomeruli of the accessory olfactory bulb (AOB). Axons of VSNs expressing the same vomeronasal receptor coalesce into multiple glomeruli within spatially conserved regions of the AOB. Here we examine the role of the Kirrel family of transmembrane proteins in the coalescence of VSN axons within the AOB. We find that Kirrel2 and Kirrel3 are differentially expressed in subpopulations of VSNs and that their expression is regulated by activity. Although Kirrel3 expression is not required for early axonal guidance events, such as fasciculation of the vomeronasal tract and segregation of apical and basal VSN axons in the AOB, it is necessary for proper coalescence of axons into glomeruli. Ablation of Kirrel3 expression results in disorganization of the glomerular layer of the posterior AOB and formation of fewer, larger glomeruli. Furthermore, Kirrel3 −/− mice display a loss of male-male aggression in a resident-intruder assay. Taken together, our results indicate that differential expression of Kirrels on vomeronasal axons generates a molecular code that dictates their proper coalescence into glomeruli within the AOB.

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Section: Aob Glomerular Map and The Control Of Pheromonal Responsesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression

et al. 2013

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“…Robo proteins are cell surface receptors that bind to the secreted ligand Slit. Signaling via Robo receptor activation plays diverse roles in shaping the developing nervous system, including axon targeting, synaptogenesis and cell migration (Campbell et al, 2007;Cho et al, 2007;Cho et al, 2011;Dickson and Gilestro, 2006;Xiao et al, 2011). Robo/Slit signaling can exert either positive or negative influences on axonal growth and branching, in some cases having both effects on the same cell (Ma and Tessier-Lavigne, 2007;Ypsilanti et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

et al. 2012

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SUMMARYHow neurons connect to form functional circuits is central to the understanding of the development and function of the nervous system. In the somatosensory system, perception of sensory stimuli to the head requires specific connections between trigeminal sensory neurons and their many target areas in the central nervous system. Different trigeminal subtypes have specialized functions and downstream circuits, but it has remained unclear how subtype-specific axonal projection patterns are formed. Using zebrafish as a model system, we followed the development of two trigeminal sensory neuron subtypes: one that expresses trpa1b, a nociceptive channel important for sensing environmental chemicals; and a distinct subtype labeled by an islet1 reporter (Isl1SS). We found that Trpa1b and Isl1SS neurons have overall similar axon trajectories but different branching morphologies and distributions of presynaptic sites. Compared with Trpa1b neurons, Isl1SS neurons display reduced branch growth and synaptogenesis at the hindbrain-spinal cord junction. The subtype-specific morphogenesis of Isl1SS neurons depends on the guidance receptor Robo2. robo2 is preferentially expressed in the Isl1SS subset and inhibits branch growth and synaptogenesis. In the absence of Robo2, Isl1SS afferents acquire many of the characteristics of Trpa1b afferents. These results reveal that subtypespecific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.

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“…GT (Serafini et al, 1996) and OMP-Cre (Cho et al, 2011;Eggan et al, 2004) mouse lines have been described previously. All animal procedures have been approved by the Montreal Neurological Institute Animal Care Committee, in accordance with the guidelines of the Canadian Council of Animal Care.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…ISH was performed on OE cryosections from embryos as previously described (Cho et al, 2011;Prince et al, 2009). …”

Section: In Situ Hybridization (Ish)mentioning

confidence: 99%

RGMB and neogenin control cell differentiation in the developing olfactory epithelium

et al. 2016

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Cellular interactions are key for the differentiation of distinct cell types within developing epithelia, yet the molecular mechanisms engaged in these interactions remain poorly understood. In the developing olfactory epithelium (OE), neural stem/progenitor cells give rise to odorant-detecting olfactory receptor neurons (ORNs) and glial-like sustentacular (SUS) cells. Here, we show in mice that the transmembrane receptor neogenin (NEO1) and its membranebound ligand RGMB control the balance of neurons and glial cells produced in the OE. In this layered epithelium, neogenin is expressed in progenitor cells, while RGMB is restricted to adjacent newly born ORNs. Ablation of Rgmb via gene-targeting increases the number of dividing progenitor cells in the OE and leads to supernumerary SUS cells. Neogenin loss-of-function phenocopies these effects observed in Rgmb −/− mice, supporting the proposal that RGMB-neogenin signaling regulates progenitor cell numbers and SUS cell production. Interestingly, Neo1−/− mice also exhibit increased apoptosis of ORNs, implicating additional ligands in the neogenin-dependent survival of ORNs. Thus, our results indicate that RGMB-neogenin-mediated cellcell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the OE.

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The Pattern of Glomerular Map Formation Defines Responsiveness to Aversive Odorants in Mice

Cited by 34 publications

References 35 publications

Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression

Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression

Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

RGMB and neogenin control cell differentiation in the developing olfactory epithelium

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