The PDGFR Receptor Family

Chiţu, Violeta; Caescu, Cristina I.; Stanley, E. Richard; Lennartsson, Johan; Rönnstrand, Lars; Heldin, Carl Henrik

doi:10.1007/978-3-319-11888-8_10

Cited by 5 publications

(10 citation statements)

References 949 publications

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“…CSF1R mutations associated with ALSP involve either missense mutations affecting highly conserved kinase domain residues or splice-site mutations leading to in-frame deletions (reviewed in [49]). Ligand-stimulated CSF-1R kinase activity was abolished for homodimeric receptors bearing each of 15 different missense mutations or each of four aberrant splice variants so far tested [40,41,47,50,51].…”

Section: Csf1r Mutations Cause Adult-onset Leukoencephalopathy With Amentioning

confidence: 99%

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

Chiţu

Gökhan

Nandi

et al. 2016

Trends in Neurosciences

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The colony stimulating factor-1 receptor (CSF-1R) kinase regulates tissue macrophage homeostasis, osteoclastogenesis, and Paneth cell development. However, recent studies in mice have revealed that CSF-1R signaling directly controls the development and maintenance of microglia, and cell autonomously regulates neuronal differentiation and survival. While the CSF-1R-cognate ligands, CSF-1 and interleukin-34 (IL-34), compete for binding to the CSF-1R, they are expressed in a largely non-overlapping manner by mature neurons. The recent identification of a dominantly inherited, adult-onset, progressive dementia associated with inactivating mutations in the CSF-1R highlights the importance of CSF-1R signaling in the brain. We review the roles of the CSF-1R and its ligands in microglial and neural development and function, and their relevance to our understanding of neurodegenerative disease.

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Section: Csf1r Mutations Cause Adult-onset Leukoencephalopathy With Amentioning

confidence: 99%

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

Chiţu

Gökhan

Nandi

et al. 2016

Trends in Neurosciences

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279

227

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“…In mouse, the equivalent monocyte subset, Ly6C + , can infiltrate the brain, differentiate into perivascular MΦ, which maintain the blood–brain barrier (Audoy-Remus et al, 2008) and have neuroprotective functions following brain or spinal cord injury (Bellavance, Gosselin, Yong, Stys, & Rivest, 2015; Shechter et al, 2013). Thus, it would be of interest to establish whether the loss of the Ly6C + subset contributes to the pathogenesis of ALSP in a mouse model (Chitu, Gokhan, et al, 2015). …”

Section: The Csf-1r In Mononuclear Phagocyte Developmentmentioning

confidence: 99%

“…Apart from its expression on cells of hematopoietic origin (macrophages, osteoclasts, dendritic cells, and their precursors), the CSF-1R is also expressed on nonhematopoietic cells (reviewed in Chitu, Caescu, et al, 2015; Chitu, Gokhan, Nandi, Mehler, & Stanley, 2016; Chitu & Stanley, 2006), including Paneth cells (PC) (Huynh et al, 2009), epithelial intestinal cells of the colon (Huynh et al, 2013), renal proximal tubule epithelial cells (Menke et al, 2009), neural progenitor cells (NPCs; Nandi et al, 2012), and several subpopulations of neurons (Luo et al, 2013; Nandi et al, 2012; Wang, Berezovska, & Fedoroff, 1999), oocytes, preimplantation embryos, decidual, and trophoblastic cells (Arceci, Pampfer, & Pollard, 1992; Arceci, Shanahan, Stanley, & Pollard, 1989; Pampfer, Arceci, & Pollard, 1991; Regenstreif & Rossant, 1989; Sasmono et al, 2003). In man, two separate CSF1R promoters drive expression in myeloid cells and cells of the trophoblast (Visvader & Verma, 1989).…”

Section: Introductionmentioning

confidence: 99%

“…Although slightly attenuated, these phenotypes are reproduced in Csf1 op/op mice (Chitu, Caescu, et al, 2015). In contrast, Il34 −/− mice are grossly normal (Greter et al, 2012; Wang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…We discuss its major role in the regulation of mononuclear phagocyte development, osteoclastogenesis, and bone formation and its direct regulation of other cell types. The functions of the CSF-1R in the adult have recently been discussed in a comprehensive review (Chitu, Caescu, et al, 2015). The present review complements other focused reviews from this laboratory of CSF-1R signaling in myeloid cells (Pixley & Stanley, 2004; Stanley & Chitu, 2014), CSF-1 in immunity and inflammation (Chitu & Stanley, 2006), and of the CSF-1R and its ligands in brain (Chitu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

Chiţu

Stanley

2017

Current Topics in Developmental Biology

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118

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Macrophages are found in all tissues and regulate tissue morphogenesis during development through trophic and scavenger functions. The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) is the major regulator of tissue macrophage development and maintenance. In combination with receptor activator of nuclear factor κB (RANK), the CSF-1R also regulates the differentiation of the bone-resorbing osteoclast and controls bone remodeling during embryonic and early postnatal development. CSF-1R-regulated macrophages play trophic and remodeling roles in development. Outside the mononuclear phagocytic system, the CSF-1R directly regulates neuronal survival and differentiation, the development of intestinal Paneth cells and of preimplantation embryos, as well as trophoblast innate immune function. Consistent with the pleiotropic roles of the receptor during development, CSF-1R deficiency in most mouse strains causes embryonic or perinatal death and the surviving mice exhibit multiple developmental and functional deficits. The CSF-1R is activated by two dimeric glycoprotein ligands, CSF-1, and interleukin-34 (IL-34). Homozygous Csf1-null mutations phenocopy most of the deficits of Csf1r-null mice. In contrast, Il34-null mice have no gross phenotype, except for decreased numbers of Langerhans cells and microglia, indicating that CSF-1 plays the major developmental role. Homozygous inactivating mutations of the Csf1r or its ligands have not been reported in man. However, heterozygous inactivating mutations in the Csf1r lead to a dominantly inherited adult-onset progressive dementia, highlighting the importance of CSF-1R signaling in the brain.

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Molecular mechanisms of cognitive impairment associated with stroke

Kaur¹,

Sharma²

2022

Metab Brain Dis

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The PDGFR Receptor Family

Cited by 5 publications

References 949 publications

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

Molecular mechanisms of cognitive impairment associated with stroke

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