The Peguero-Lo Presti Electrocardiographic Criteria Predict All-Cause Mortality in Patients With Aortic Stenosis

Ramchand, Jay; Rodrigues, Thalys Sampaio; Kearney, L.; Patel, Sheila K.; Srivastava, Piyush; Burrell, Louise M.

doi:10.1016/j.jacc.2017.05.084

Cited by 11 publications

(17 citation statements)

References 1 publication

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“…After the original publication of the Peguero-Lo Presti criterion several other groups compared the sensitivity of the novel electrocardiographic criterion with other ECG criteria with conflicting results 32 , 38 – 45 . The PLP criterion also predicted LVH in another cohort of patients with aortic stenosis 46 and mortality in a clustered probability sample of the general population 5 . Also, in a cohort of apparently healthy individuals 47 , the specificity of the PLP criterion seemed to be higher in older rather than young individuals.…”

Section: Discussionmentioning

confidence: 90%

Clinical applicability and diagnostic performance of electrocardiographic criteria for left ventricular hypertrophy diagnosis in older adults

Tavares

Samesima

Hajjar

et al. 2021

Sci Rep

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Recently, a new ECG criterion, the Peguero-Lo Presti (PLP), improved overall accuracy in the diagnosis of left ventricular hypertrophy (LVH)—compared to traditional ECG criteria, but with few patients with advanced age. We analyzed patients with older age and examined which ECG criteria would have better overall performance. A total of 592 patients were included (83.1% with hypertension, mean age of 77.5 years) and the PLP criterion was compared against Cornell voltage (CV), Sokolow-Lyon voltage (SL) and Romhilt-Estes criteria (cutoffs of 4 and 5 points, RE4 and RE5, respectively) using LVH defined by the echocardiogram as the gold standard. The PLP had higher AUC than the CV, RE and SL (respectively, 0.70 vs 0.66 vs 0.64 vs 0.67), increased sensitivity compared with the SL, CV and RE5 (respectively, 51.9% [95% CI 45.4–58.3%] vs 28.2% [95% CI 22.6–34.4%], p < 0.0001; vs 35.3% [95% CI 29.2–41.7%], p < 0.0001; vs 44.4% [95% CI 38.0–50.9%], p = 0.042), highest F1 score (58.3%) and net benefit for most of the 20–60% threshold range in the decision curve analysis. Overall, despite the best diagnostic performance in older patients, the PLP criterion cannot rule out LVH consistently but can potentially be used to guide clinical decision for echocardiogram ordering in low-resource settings.

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Section: Discussionmentioning

confidence: 90%

Clinical applicability and diagnostic performance of electrocardiographic criteria for left ventricular hypertrophy diagnosis in older adults

Tavares

Samesima

Hajjar

et al. 2021

Sci Rep

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“…The small sample size and the patient-based population were just a few of the study limitations. ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Peguero Electrocardiographic Left Ventricular Hypertrophy Criteria and Risk of Mortality

Afify

Waits

Ghoneum

et al. 2018

Front. Cardiovasc. Med.

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Background: Peguero electrocardiographic left ventricular hypertrophy (ECG-LVH) criteria are newly developed criteria that have shown better diagnostic performance than the traditional Cornell-voltage and Sokolow-Lyon criteria. However, prediction of poor outcomes rather than detection of increased left ventricular mass is becoming the primary use for ECG-LVH criteria which requires investigating any new ECG-LVH criteria in terms of prediction.Aims: To examine the prognostic significance of the newly developed Peguero ECG-LVH criteria.Methods: We compared the prognostic significance of Peguero ECG-LVH with Cornell-voltage and Sokolow-Lyon ECG-LVH criteria in 7,825 participants (age 59.8 ± 13.4 years; 52.7% women) from the third National Health and Nutrition Examination Survey who were free of major intraventricular conduction defects. ECG-LVH criteria were derived from digital ECG tracings processed at a central core laboratory.Results: At baseline, ECG-LVH was detected in 11.8% by Peguero; in 4.3% by Cornell voltage and in 6.4% by Sokolow-Lyon. During a median follow up of 13.8 years, 2,796 all-cause mortality events occurred. In multivariable models adjusted for demographics and cardiovascular risk factors, presence of Peguero ECG-LVH was associated with increased risk of all-cause mortality [HR (95% CI): 1.29 (1.16, 1.44)]. This association was not significantly different from the associations of Cornell voltage-LVH or Sokolow-Lyon LVH with all-cause mortality [HR (95%CI): 1.32 (1.12, 1.55) and 1.24 (1.07, 1.43), respectively; p-values for comparisons of these HRs with the HR of Peguero ECG-LVH 0.817 and 0.667, respectively]. Similar patterns of associations were observed with cardiovascular, ischemic heart disease and heart failure mortalities.Conclusion: Peguero ECG-LVH is predictive of increased risk of death similar to the traditional ECG-LVH criteria.

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“…For instance, Peguero‐Lo Presti LVH was shown to be an independent predictor of all‐cause mortality in a group of patients with aortic stenosis. 20 …”

Section: Discussionmentioning

confidence: 99%

Accuracy of the novel Peguero Lo‐Presti criterion for electrocardiographic detection of left ventricular hypertrophy in a black African population

Nyaga¹,

Boombhi

Menanga

et al. 2021

J of Clinical Hypertension

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Left ventricular hypertrophy (LVH), a maladaptive response to chronic pressure overload, is a marker of subclinical cardiac disease and a predictor of arrhythmias, heart failure, and death. 1,2 Because LVH is potentially reversible, its early detection and appropriate management of its underlying cause can prevent related adverse cardiovascular outcomes. 3 In routine clinical practice, LVH is usually

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The Peguero-Lo Presti Electrocardiographic Criteria Predict All-Cause Mortality in Patients With Aortic Stenosis

Cited by 11 publications

References 1 publication

Clinical applicability and diagnostic performance of electrocardiographic criteria for left ventricular hypertrophy diagnosis in older adults

Clinical applicability and diagnostic performance of electrocardiographic criteria for left ventricular hypertrophy diagnosis in older adults

Peguero Electrocardiographic Left Ventricular Hypertrophy Criteria and Risk of Mortality

Accuracy of the novel Peguero Lo‐Presti criterion for electrocardiographic detection of left ventricular hypertrophy in a black African population

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