The Penetration of Ciprofloxacin into Human Pancreatic and Peripancreatic Necroses in Acute Necrotizing Pancreatitis

Abstract

Due to its antimicrobial spectrum and the good penetration into the relevant compartments, CIP may be useful in preventing local infection in necrotizing pancreatitis.

Pathologic alterations detected in acute pancreatitis induced by sodium taurocholate in rats and therapeutic effects of curcumin, ciprofloxacin and metronidazole combination

“…The species of the bacteria isolated in the study complies with those reported in the literature [5,8,27] . Antibiotic administration was initiated six hours after induction of AP, since necrosis was reported to become apparent within this period [9] .…”

The Penetration of Moxifloxacin into the Pancreas of Male Rats in Experimental Acute Necrotizing Pancreatitis

“…Some fluoroquinolones, e.g. ciprofloxacin, penetrate pancreatic as well as necrotic tissue sufficiently, with tissue concentrations above the corresponding serum levels, as we were able to demonstrate in our own studies [12].…”

“…Fluoroquinolones are known to penetrate the pancreas sufficiently to reach high tissue concentrations [12]. Older quinolones such as ciprofloxacin and ofloxacin were therefore the drugs of choice for the treatment of pancreatic infections.…”

Acute pancreatitis secondary to ciprofloxacin therapy in patients with infectious colitis

“…2 In the pancreatic field, ciprofloxacin can be a useful tool as an empirical therapy in necrotizing pancreatitis to prevent secondary bacterial infection, [8][9][10][11] because ciprofloxacin penetrates the human pancreas very well. 12,13 However, ironically, it is claimed that the ciprofloxacin can, in rare cases, cause drug-induced pancreatitis. Until now, there has only been one case report associated with ciprofloxacin in the literature.…”