This experimental study paper investigation mainly focused on CI engine performance with using the palm oil methyl ester (POME). The injection timing (IT) varied from 19° btdc, 23° btdc, 27° btdc and 31° btdc with increment step of 4° CA and similarly, injection opening pressure were varied from 210 bar, 220bar, 230 bar, 240 bar and 250 bar with increment order of 10 bar in the existed diesel engine. The final results were reported for optimized parameters of diesel engine with engine speed 1500 rpm and CR 17.5. The experimental results of diesel engine performance improved in terms of brake thermal efficiency (BTE) and substantial reduction of harmful emissions at both optimized engine parameters of 27°BTDC and 240 bar, when engine has powered with Palm oil methyl ester (POME) as a alternative fuel.