The perfusion of surviving organs

Brodie, T. G.

doi:10.1113/jphysiol.1903.sp000954

Cited by 73 publications

(26 citation statements)

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“…The development of reliable perfusion pumps allowed the use of artificial perfusion circuits to study the physiology of organ function [3]. These kinds of studies were further facilitated by replacement of blood by synthetic perfusates -solutions of electrolytes, solutes, and vitamins [4,5].…”

Section: History Of Organ Preservation For Transplantationmentioning

confidence: 99%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

285

233

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Organ transplantation has developed over the past 50 years to reach the sophisticated and integrated clinical service of today through several advances in science. One of the most important of these has been the ability to apply organ preservation protocols to deliver donor organs of high quality, via a network of organ exchange to match the most suitable recipient patient to the best available organ, capable of rapid resumption of life-sustaining function in the recipient patient. This has only been possible by amassing a good understanding of the potential effects of hypoxic injury on donated organs, and how to prevent these by applying organ preservation. This review sets out the history of organ preservation, how applications of hypothermia have become central to the process, and what the current status is for the range of solid organs commonly transplanted. The science of organ preservation is constantly being updated with new knowledge and ideas, and the review also discusses what innovations are coming close to clinical reality to meet the growing demands for high quality organs in transplantation over the next few years.

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Section: History Of Organ Preservation For Transplantationmentioning

confidence: 99%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

285

233

View full text Add to dashboard Cite

show abstract

“…Thus, Brodie (1903) stressed the need for adequate oxygen, and Grube (1903) the necessity for rapidly re-establishing the liver circulation after dissection. Belt, Smith & Whipple (1920) proposed that some normal function of the organ in vivo should be possessed by the perfused organ.…”

Section: Discussionmentioning

confidence: 99%

The potassium, water and glycogen contents of the perfused rat liver

D'Silva¹,

Neil²

1954

The Journal of Physiology

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“…It was suggested that a vasoconstrictive substance formed during clotting was partly responsible (Stevens, 1884;Brodie, 1903). The presence of a vasoconstrictive substance in extracts of platelets was subsequently confirmed (Stewart & Zucker, 1913;Janeway et al, 1918).…”

Section: The Discovery Of Serotoninmentioning

confidence: 95%

The Serotonin Hypothesis of Schizophrenia: A Historical Case Study on the Heuristic Value of Theory in Clinical Neuroscience

Baumeister

Hawkins

2004

Journal of the History of the Neurosciences

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Clinical examination of the reliability and coherence of the evidence concerning modern neurochemical theories of mental disorders has led some scholars to conclude that support for many of these theories is weak. Nevertheless, these theories continue to be widely promoted. One explanation that has been offered for continued adherence to questionable theory is that it stimulates and gives direction to research. The heuristic value of theory is examined in the present paper by tracing the discoveries that followed from an old theory of schizophrenia, which is--by current consensus--false. It is shown that the original serotonin hypothesis of schizophrenia did, in fact, lead to significant advances in neuropharmacology, neurology and psychiatry.

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The perfusion of surviving organs

Cited by 73 publications

References 0 publications

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Organ Preservation: Current Concepts and New Strategies for the Next Decade

The potassium, water and glycogen contents of the perfused rat liver

The Serotonin Hypothesis of Schizophrenia: A Historical Case Study on the Heuristic Value of Theory in Clinical Neuroscience

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