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and the Royal College of Surgeons, England.)IN carrying out some experiments with antitoxic serum I was surprised to find that the intravenous injection of diluted blood-serum into a cat produced a marked effect upon the heart and respiration.As serum is now being extensively used for therapeutic purposes I thought it would be well to follow this observation further. At the outset I must mention, that of the animals tested, dog, cat and rabbit, the effect is only to be observed in the cat. A second important point is that it is not a particular property of antitoxic serum for it can be obtained by injecting serum from any source, including even the serum obtained from the particular animal experimented upon. It was also found that several other substances, e.g. egg-white and the bromine compounds of proteids, could produce the same effect but in the experiments described in this paper serum has been chiefly employed. It may be mentioned that milk has a slight effect, but gelatine and peptone have none.That serum is by no means an innocuous substance when injected subcutaneously or intravenously into an animal is already well known, but I need only refer to the most recent papers upon this subject. Weiss' describes a long series of experiments dealing with the toxicity of serum. The serum from all species of animal tested was invariably found to be toxic, though possessing different degrees of toxicity, and caused death if a sufficient quantity was injected. The symptoms 1 Weiss.