The Permeability of Bull Spermatozoa to Water, Polyhydric Alcohols and Univalent Anions and the Effects of the Anions Upon the Kinetic Activity of Spermatozoa and Sperm Models

Drevius, L.-O.

doi:10.1530/jrf.0.0280041

Cited by 45 publications

(13 citation statements)

References 25 publications

(38 reference statements)

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“…The bovine spermatozoa have the ability to swell in a hypo osmotic medium (Drevius and Eriksson, 1966;Bredderman and Foote, 1969;Drevius, 1972). The study conducted by Salah et al, confirmed the ability with an average swelling close to that reported for human spermatozoa using the same hypo osmotic solution (Jeyendran et al, 1984).…”

Section: Effect Of Thi On % Live Sperm Of Semensupporting

confidence: 72%

Effect of Temperature Humidity Index on Semen Quality of Bovine Bull

Sharma¹,

Bhat²,

Singh³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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Section: Effect Of Thi On % Live Sperm Of Semensupporting

confidence: 72%

Effect of Temperature Humidity Index on Semen Quality of Bovine Bull

Sharma¹,

Bhat²,

Singh³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…Possible Modification Drevius (1972c) found that bovine sperm were more permeable to anions than cations and suggested that sperm membrane pores may be positively charged. The incorporation of sperm membrane protein into artificial lipid bilayers has revealed the existence of many channels: nonselective cation channels in mature (epididymal and ejaculated) porcine spermatozoa (Cox et al, 1991) and K ϩ -selective (TEA-sensitive), Na ϩ -selective, divalent cation-and anion-permeable channels in rat epididymal and human ejaculated spermatozoa (Chan et al, 1997;Shi and Ma, 1998;Ma and Shi, 1999).…”

Section: Anion and Cation Channels And Theirmentioning

confidence: 99%

Acquisition of volume regulatory response of sperm upon maturation in the epididymis and the role of the cytoplasmic droplet

Cooper¹,

Yeung²

2003

Microscopy Res & Technique

171

134

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In certain cases of infertility in domestic species, and in the homozygous c-ros tyrosine kinase knockout mouse, males are infertile as a result of unopposed sperm swelling. This induces flagellar angulation, preventing their normal migration in the female tract. Angulation always occurs at the site of the cytoplasmic droplet located in mature sperm at the annulus (midpiece - principal piece junction). This article reviews the literature on the fate of the sperm's cytoplasmic droplet and suggests a role for it in volume regulation. A hypothesis is presented that during epididymal transit sperm acquire osmolytes accumulated by the epididymal epithelium. This is possibly driven by a mechanism of regulatory volume increase invoked by the hypertonicity of epididymal luminal fluid. These osmolytes are subsequently used for regulatory volume decrease after ejaculation into the relatively hypotonic female tract. Study of the mechanisms of sperm volume regulation may highlight new contraceptive leads.

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“…The permeability of spermatozoa to a variety of low molecular weight soluble compounds was first examined by Drevius (1971Drevius ( , 1972, in which spermolysis and spermatocrit measurements were taken as indices of the swelling of bovine epididymal spermatozoa. These studies were done at the osmolality of epididymal fluid (c. 353 mmol/kg) where swelling reflects the permeability of the unstressed membrane of the non-swollen cell to the compounds added at high concentration that enter the cell drawing water with them.…”

Section: Permeability Of Spermatozoamentioning

confidence: 99%

The tonicity of murine epididymal spermatozoa and their permeability towards common cryoprotectants and epididymal osmolytes

Cooper¹,

Barfield²,

Yeung³

2008

Reproduction

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The permeability of murine cauda epididymidal spermatozoa was determined from the swelling caused by penetrating agents at isotonicity, which lies between 422 and 530 mmol/kg. Spermatozoa were permeable to a range of solutes with size !200 Da. Relative entry rates of cryoprotective agents (CPAs) were ethylene glycolzDMSOOpropane-1,2-diolOglycerolOpropane-1,3-diol. More polar compounds including major epididymal secretions were impermeant. None of the compounds entered spermatozoa through quininesensitive channels; rather, quinine increased the size of solute-swollen spermatozoa, suggesting that regulatory volume decrease and osmolyte loss occurred under these conditions. Volume responses to lowered osmolality revealed a greater volume-regulating ability of spermatozoa from the B6D2F1 strain than the C57BL6 strain. As the former strain displays better post-thaw fertility, their spermatozoa may have greater osmolyte loads enabling them to cope better with osmotic stress. Inadequate volume regulation, due to CPA-induced osmolyte loss, may affect post-thaw fertility. Knowing the permeability towards cryoprotectants will help to make a better choice of CPAs that are less damaging to sperm during cryopreservation. Reproduction (2008) 135 625-633

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The Permeability of Bull Spermatozoa to Water, Polyhydric Alcohols and Univalent Anions and the Effects of the Anions Upon the Kinetic Activity of Spermatozoa and Sperm Models

Abstract: Summary. The

Cited by 45 publications

References 25 publications

Effect of Temperature Humidity Index on Semen Quality of Bovine Bull

Effect of Temperature Humidity Index on Semen Quality of Bovine Bull

Acquisition of volume regulatory response of sperm upon maturation in the epididymis and the role of the cytoplasmic droplet

The tonicity of murine epididymal spermatozoa and their permeability towards common cryoprotectants and epididymal osmolytes

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