The permeability of keratinized and nonkeratinized oral epithelium to lanthanum in vivo

Squier, C. A.; Rooney, Lynn

doi:10.1016/s0022-5320(76)80157-8

Cited by 112 publications

(37 citation statements)

References 28 publications

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“…In keratinized mucosa from several oral sites, the limit of penetration of the tracers was at the boundary of the granular and keratinized layers, as in epidermis. 37 - 38 At this level in the tissue, the contents of the membrane-coating granules, which have a similar structure to those of epidermis, 41 are extruded. When the procedure was carried out using nonkeratinized oral mucosa, the tracers failed to penetrate the outer one third to one quarter of the epithelium.…”

Section: A Superficial Barriersmentioning

confidence: 99%

Permeability of Oral Mucosa

Squier¹,

Johnson²

1975

British Medical Bulletin

113

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ABSTRACT:In discussing permeability, we are describing one of the fundamental barrier functions of oral mucosa. Despite assumptions to the contrary, the oral mucosa is not a uniformly, highly permeable tissue like gut, but shows regional variation. The keratinized areas, such as gingiva and hard palate, are least permeable and nonkeratinized lining areas are most permeable. This variation appears to reflect differences in the types of lipid making up the intercellular permeability barrier in the superficial layers of the epithelium. Differences in permeability may be related to regional differences in the prevalence of certain mucosal diseases and can be utilized to advantage for local and systemic drug delivery.

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Section: A Superficial Barriersmentioning

confidence: 99%

Permeability of Oral Mucosa

Squier¹,

Johnson²

1975

British Medical Bulletin

113

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“…He suggests that this may be a pointless pursuit, mainly since even non-keratinized epithelia may offer resistance to the penetration of many substances (35,38) and 41 (1983) since keratinization of the highly permeable (28,30) junctional epithelium may lead to loss of epithelial attachment to the tooth surface and thus be harmful. Although this latter point may be well taken, it should be kept in mind that in spite of the intensive antibacterial therapy over considerable periods of time in this and other (2, 5 , 32) studies, keratinization of the junctional epithelium in situ has never been reported as a result of antibacterial therapy and may not be readily achieved (30,41).…”

Section: Discussionmentioning

confidence: 99%

“…Although an orthokeratinized stratum corneum probably constitutes a highly impermeable membrane (9), several studies indicate that a significant permeability barrier is present in the stratum granulosum of keratinized epithelia and in corresponding layers of non-keratinized oral epithelia (9,35,38). This barrier coincides with the appearance of MCG, which release their contents into the intercellular spaces, (16) and often with thickened cytoplasmic membranes or 'marginal band' (13).…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Study of Induced Keratinization in Sulcular Gingival Epithelium in Rhesus Monkeys

Kristoffersen

Caffesse

Nasjleti

et al. 1983

Acta Odontologica Scandinavica

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Gingival sulcular epithelium--which in primates normally does not keratinize--can be induced to undergo keratinization by prolonged intensive antibacterial therapy. Three months before biopsy the teeth of two adult male rhesus monkeys were scaled and polished, and for 5 days the monkeys were given intravenous injections of 75 mg Achromycin daily. Their teeth were subsequently subjected to daily cleaning and polishing. The presumably in-situ-keratinized sulcular epithelium was examined by transmission electron microscopy. It was also compared with oral gingival epithelium from the same two animals and with oral and sulcular epithelium from a rhesus monkey that had not been exposed to local or systemic antibacterial therapy. The results confirmed earlier histological studies, which have shown that under the conditions described the sulcular epithelium becomes parakeratinized. In addition, several other ultrastructural changes were observed, some of which suggest that the treatment given may result in the formation of a more efficient permeability barrier in the sulcular area. The possible clinical significance of such a barrier is briefly discussed.

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“…Permeation studies with horseradish peroxidase [5] and lanthanum nitrate [6] have shown that the flattened superficial layers constitute the major barrier, while the lower layers are relatively permeable. This is true in both keratinized and nonkeratinized epithelium, suggesting that keratinization does not offer as much resistance to buccal drug permeation as once thought.…”

Section: Epitheliummentioning

confidence: 99%

Anatomy and Physiology of the Oral Mucosa

Johnston¹

2015

Advances in Delivery Science and Technology

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The permeability of keratinized and nonkeratinized oral epithelium to lanthanum in vivo

Cited by 112 publications

References 28 publications

Permeability of Oral Mucosa

Permeability of Oral Mucosa

Ultrastructural Study of Induced Keratinization in Sulcular Gingival Epithelium in Rhesus Monkeys

Anatomy and Physiology of the Oral Mucosa

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