The persistence of chronic spontaneous urticaria in childhood is associated with the urticaria activity score

Abstract

The etiology of CSU in children was mostly idiopathic despite detailed investigation. In childhood, the natural course of CSU was favorable, and nearly half of the patients recovered after 5 years of disease duration. A high UAS7 at admission seemed to be a significant risk factor for the persistence of symptoms.

Urticaria in children and adolescents: An updated review of the pathogenesis and management

“…Isolated wheals appear in 78.4% of cases, angioedema in 6.65%, while both symptoms are observed in 15% of cases . In children, accompanying angioedema was reported in 48.2% cases …”

Modern Possibilities of Chronic Urticaria Therapy in Children

“…Хроническая кра-пивница выраженно снижает качество жизни ребенка, ухудшает ночной сон, влияет на успеваемость в школе, в том числе из-за пропусков занятий в связи с частыми обострениями [5,6]. Заболевание оказывает отрица-тельное влияние на качество жизни не только самого ребенка, но и его семьи и окружения [1,7].…”

Hydroxychloroquine as a steroid-sparing agent in an infant with chronic urticaria

“…However, we believe this is unlikely given the severity of our patient’s urticaria and need for combination therapy, which are risk factors for persistent disease. 5,10 Furthermore, a recent study of children with CSU observed remission in only 10.6% and 44.5% of patients at 1 and 5 years, respectively. 5 Although further study is needed, this case demonstrates that hydroxychloroquine can be a safe and potentially effective therapeutic option for antihistamine-refractory CSU in children, allowing for concomitant discontinuation of steroids.…”

“…4 Childhood CSU is sometimes associated with infections, atopy, autoimmunity and physical urticarias, but most cases are idiopathic. 5 Although large clinical studies are lacking, many children with recurrent urticaria appear to respond favorably to antihistamines. 6 However, the optimal management of antihistamine-refractory CSU in children is unknown.…”