The phagocytic function of blood-derived polymorphonuclear neutrophils after administration of dexamethasone for the modulation of post-breeding endometritis in the mare

Öhman, Taina; Klein, Cynthia; Doty, Andria; Troedsson, M.H.T.

doi:10.21836/pem20110310

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…A reduction of pro-inflammatory IL1β, CXCL8, and SAA and suppression of inflammatory mediators, such as COX-2, lipo-oxygenase 5, and NO, were reported after dexamethasone therapy, while an increase in the inflammatory modulating and anti-inflammatory IL6, IL10, and IL1RN was also observed after treatment [33]. Additionally, the administration of dexamethasone altered the production of acute-phase proteins following bacterial challenge [295] and did not alter the phagocytic function of blood-derived PMNs [296], which could predispose the mare to a secondary infection. This alteration in the acute phase protein profile has also been noted following treatment with prednisolone [297].…”

Section: Immunomodulatory Agentsmentioning

confidence: 95%

Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology

Canisso

Segabinazzi

Fedorka

2020

IJMS

105

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Post-breeding endometritis (i.e., inflammation/infection of the endometrium), is a physiological reaction taking place in the endometrium of mares within 48 h post-breeding, aimed to clear seminal plasma, excess sperm, microorganisms, and debris from the uterine lumen in preparation for the arrival of an embryo. Mares are classified as susceptible or resistant to persistent breeding-induced endometritis (PBIE) based on their ability to clear this inflammation/infection by 48 h post-breeding. Mares susceptible to PBIE, or those with difficulty clearing infection/inflammation, have a deficient immune response and compromised physical mechanisms of defense against infection. Molecular pathways of the innate immune response known to be involved in PBIE are discussed herein. The role of the adaptive uterine immune response on PBIE remains to be elucidated in horses. Advances in the pathobiology of microbes involved in PBIE are also revised here. Traditional and non-traditional therapeutic modalities for endometritis are contrasted and described in the context of clinical and molecular aspects. In recent years, the lack of efficacy of traditional therapeutic modalities, alongside the ever-increasing incidence of antibiotic-resistant microorganisms, has enforced the development of non-traditional therapies. Novel biological products capable of modulating the endometrial inflammatory response are also discussed here as part of the non-traditional therapies for endometritis.

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Section: Immunomodulatory Agentsmentioning

confidence: 95%

Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology

Canisso

Segabinazzi

Fedorka

2020

IJMS

105

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“…Inflammation associated with the innate immune system results in fluid production into uterine lumen. [3][4][5] Final defense mechanism against bacterial endometritis is mechanical uterine clearance of bacteria and inflammatory products. Mares susceptible to uterine infections have decreased clearance of uterine fluid compared to resistant mares.…”

Section: Pathophysiologymentioning

confidence: 99%

Biofilm and latent bacteria in equine uterus

Ferris

2022

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Subfertility in the mare can be frustrating to the clinician. Recent data suggested that bacteria in either a biofilm or latent state may be responsible for certain cases of subfertility. Recent work has identified the pathophysiology for these types of chronic infections in the mare and best methods for therapy. The goal is to elucidate the pathophysiology of biofilm and latent infections and the diagnosis, and treatment of these types of infections in clinical practice.

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