1997
DOI: 10.1007/s004649900482
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The phagocytosis activity during conventional and laparoscopic operations in the rat

Abstract: Background: Numerous experimental and clinical investigations indicate that the mononuclear phagocyte system (MPS) has a relevant function in terms of physiological defense against tumor metastasis and bacterial infection. Consequently, a point of major interest is the influence of surgical techniques on the MPS function. Method: The model investigation examines the phagocytosis activity of the rat's MPS during conventional fundoplication (group 1, n ‫ס‬ 10), laparoscopic fundoplication using a pneumoperitoneu… Show more

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Cited by 53 publications
(48 citation statements)
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“…Previous experimental data showed an impaired function of systemic and peritoneal macrophages with CO 2 pneumoperitoneum as compared to open surgery [25,26]. With regard to reports about a better preserved systemic inflammatory response, intraperitoneal cell-mediated immunity and protease activity in helium pneumoperitoneum, a similar advantageous effect on macrophages and wound healing was assumed [19][20][21].…”
Section: Discussionmentioning
confidence: 85%
“…Previous experimental data showed an impaired function of systemic and peritoneal macrophages with CO 2 pneumoperitoneum as compared to open surgery [25,26]. With regard to reports about a better preserved systemic inflammatory response, intraperitoneal cell-mediated immunity and protease activity in helium pneumoperitoneum, a similar advantageous effect on macrophages and wound healing was assumed [19][20][21].…”
Section: Discussionmentioning
confidence: 85%
“…In a second experimental design we wanted to characterize the effects of O 2 /O 3 pneumoperitoneum on the immune system by analyzing the production of pro-inflammatory cytokines in several lymphoid organs within the abdomen. For this, we used a more reductionistic animal model (nonsurgical model) to reduce all possible immunotraumatic influences on infection caused by anesthesia and surgical trauma [15,16]. In this model we only analyzed the ozone concentrations, which had shown a highly significant biological effect in the surgical model.…”
Section: Introductionmentioning
confidence: 99%
“…A higher rate of recurrence has been reported in patients with cancer receiving transfusion [13] but could not be confirmed by other investigators [14]. A negative effect on phagocytosis also is described after using a pneumoperitoneum for laparoscopic surgery [15]. We incubated whole blood samples of healthy probands with red blood cell packs (RCP), fresh frozen plasma (FFP) and 10% HAES to investigate seperately the influence of cell remainders (RCP), amino acids (FFP), and large molecules (HAES).…”
Section: Introductionmentioning
confidence: 72%