The pharmacokinetics and effects of intravenously administered carprofen and salicylate on gastrointestinal mucosa and selected biochemical measurements in healthy cats

Abstract

The pharmacokinetics of carprofen, a propionic acid-derived nonsteroidal anti-inflammatory (NSAID), and its effect on gastrointestinal mucosa, complete blood counts (CBC) and biochemical indicators of liver and renal function were investigated in healthy cats using a randomized crossover design. A single dose of 4 mg/kg of carprofen (Zenecarp(R) Injection), normal saline, or 20 mg/kg of DL-lysine acetyl salicylate (Vetalgine(R)) was given intravenously (i.v.) to each of five cats with a washout period of 2 weeks between treatments. Endoscopy of the stomach and duodenum 8 h postinjection revealed one acetyl salicylate-(aspirin)-treated cat with minor pinpoint erosions. None of the other cats in the three treatment groups had evidence of bleeding or ulceration. Serum biochemistry measurements of blood urea nitrogen (BUN), alanine transferase (ALT) and alkaline phosphatase (ALP) and complete blood counts (CBC) were not significantly altered from pretreatment values by the single dose of salicylate or carprofen (P < 0.05). Early and extended sample time points suggest that the pharmacokinetics of carprofen in the cat fit a 2-compartment model, with a long elimination half-life (t1/2) of 20.1 +/- 16.6 h, an area under the plasma concentration-time curve (AUC) of 637 (+/- 237) microgram.mL/h and a volume of distribution (Vdss) of 0.14 +/- 0.05 L/kg. Intravenously administered aspirin fit a 2-compartment model and had a long elimination half-life (t1/2) of 22.2 +/- 3.1 h, an AUC of 3824.2 +/- 506.7 microgram.mL/h and a volume of distribution (Vdss) of 0.17 +/- 0. 01 L/kg.

Comparison of preoperative carprofen and postoperative butorphanol as postsurgical analgesics in cats undergoing ovariohysterectomy

“…In a recent study in cats, IV administration of carprofen at a dose of 4 mg kg −1 did not cause endoscopically recognizable gastrointestinal lesions, while 20 mg kg −1 of IV acetyl salicylate produced minor pinpoint erosions in the gastrointestinal tract of one cat 8 hours post‐injection. BUN, ALT, ALP and CBCs were not significantly altered from pretreatment values for both drugs (Parton et al. 2000).…”

Morphine, pethidine and buprenorphine disposition in the cat

“…However, age did not appear to alter total body clearance. Parton et al . (2000) found huge inter‐cat variability in pharmacokinetics of i.v.…”

Pain management in cat

“…Πρόσφατα η ειδικότητα της αποδόθηκε στο S( + ) ισομερές της (Giraudel et al 2005b). Είναι από τα ελάχιστα ΜΣΑΦ των οποίων τα φαρμακοκινητικά και φαρμακοδυναμικά χαρακτηρι στικά έχουν μελετηθεί στη γάτα (Taylor et al 1996, Parton et al 2000. Στην αναστολή της δράσης της COX-2 πιθανόν να οφείλεται η ασφάλεια της.…”