The pharmacokinetics of 2,2′,5,5′-tetrachlorobiphenyl and 3,3′,4,4′-tetrachlorobiphenyl and its relationship to toxicity

Clevenger, M.Ann; Roberts, Stephen M.; Lattin, D. L.; Harbison, Raymond D.; James, Robert C.

doi:10.1016/0041-008x(89)90317-7

Cited by 19 publications

(9 citation statements)

References 25 publications

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“…This observation is consistent with the lower absorption of the bolus dose of the 3,3’4,4’congener and with its shorter half life(Clevenger et al, 1989). Therefore after 7 days, the retained dose was less than for the 2,2’,5,5’ congener, and the daily excretion reflected the lower retention.…”

Section: Discussionsupporting

confidence: 85%

“…The ratio of concentration in the adipose relative to plasma is markedly less than those reported by Clevenger et al during 7 days after exposure of mice to this congener(Clevenger et al, 1989). However, the results in that study were obtained after 8 daily doses of 100 mg/kg body weight, which were far greater than the single bolus of approximately 2 mg/kg in our study.…”

Section: Discussioncontrasting

confidence: 63%

“…In this case the results in that study were obtained after 10 daily doses of 8 mg/kg body weight, greater than our single bolus of approximately 2 mg/kg(Clevenger et al, 1989). …”

Section: Discussionmentioning

confidence: 54%

“…It should be noted that this congener is not well absorbed, even from the high-fat diet, and olestra decreased absorption by more than 50%. This low absorption might be predicted from the high melting point (176 °C) of this coplanar congener, which reduces its solubility in and bioavailability from dietary fat(Clevenger and et al,1989). Lower absorption of this congener relative to that of the 2,2’,5,5’ congener can be inferred from previously reported adipose tissue concentrations(Clevenger et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

“…This low absorption might be predicted from the high melting point (176 °C) of this coplanar congener, which reduces its solubility in and bioavailability from dietary fat(Clevenger and et al,1989). Lower absorption of this congener relative to that of the 2,2’,5,5’ congener can be inferred from previously reported adipose tissue concentrations(Clevenger et al, 1989). There is no evidence that olestra had any further effect on removal of this congener or its metabolites from the body.…”

Section: Discussionmentioning

confidence: 99%

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The effect of olestra on the absorption, excretion and storage of 2,2′,5,5′ tetrachlorobiphenyl; 3,3′,4,4′ tetrachlorobiphenyl; and perfluorooctanoic acid

Jandacek

Rider

Keller

et al. 2010

Environment International

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Mice were gavaged with either 14C-labeled 2,2’5,5’ tetrachlorobiphenyl; 3,3’,4,4’ tetrachlorobiphenyl; or perfluorooctanoic acid. Absorption of these compounds was determined by assay of feces collected for 48 hours after the gavage. Part of the animals received test diets containing olestra during this 48-hour period to determine its effect on absorption of the compounds. Mice that received the diet without olestra during this period were divided into groups that either continued the diet without olestra or changed to a diet containing olestra. These diets were continued for 7 days, and a second 48-hour fecal collection was made to measure the effect of olestra on enterohepatic circulation of the compounds and their metabolites. The animals were sacrificed, and blood, fat, and liver concentrations of 14C were measured. Olestra decreased the absorption of 2,2’,5,5’ tetrachlorobiphenyl. It also reduced tissue and blood concentrations of this compound. Olestra also decreased the absorption of 3,3’,4,4’ tetrachlorobiphenyl, but it did not alter enterohepatic circulation or tissue concentrations. Olestra significantly increased the excretion of perfluorooctanoic acid in the second 48-hour collection, suggesting an effect on enterohepatic circulation. It did not, however, alter tissue concentrations of perfluorooctanoic acid. These data are consistent with previously observed effects of olestra on the absorption and storage of lipophilic compounds.

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 63%

“…In this case the results in that study were obtained after 10 daily doses of 8 mg/kg body weight, greater than our single bolus of approximately 2 mg/kg(Clevenger et al, 1989). …”

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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