The pharmacology of the genus Sophora (Fabaceae): An updated review

Aly, Shaza H.; Elissawy, Ahmed M.; Eldahshan, Omayma A.; El‐Shanawany, Mohamed A.; Efferth, Thomas; Singab, Abdel Nasser B.

doi:10.1016/j.phymed.2019.153070

Cited by 46 publications

(57 citation statements)

References 149 publications

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“…Several plants that belong to the Fabaceae family have been utilized in traditional medicine. Moreover, different chemical components with various biological properties have been isolated from species of the Fabaceae family including isoflavonoids, alkaloids, terpenoids and phenolic acids (Ma et al 2011 ; Aly et al 2019 ). Similarly, compounds isolated from plants belonging to the Zingiberaceae family exhibited a wide range of pharmacological activities such as antioxidant, anti-inflammatory and antimicrobial activities (Mao et al 2019 ).…”

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

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Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-021-09773-1.

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Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

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“…Natural alkaloids have been isolated from roots, seeds and epigeal parts of the plant. Sophora extracts have been used in traditional Chinese medicine [ 37 ].…”

Section: Naturally Occurring Naphthyridine Derivativesmentioning

confidence: 99%

Biological Activity of Naturally Derived Naphthyridines

2021

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Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes.

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“…The genus of Sophora (family Fabaceae) contains approximately 70 species, most of which are distributed in tropical and temperate zones serving as pesticides and/or nectariferous plants (Aly et al, 2019). Apart from these, several Sophora species including Sophora flavescens Ait (Ku shen) and Sophora subprostrata (Sang zhi huai) etc.…”

Section: Introductionmentioning

confidence: 99%

“…Apart from these, several Sophora species including Sophora flavescens Ait (Ku shen) and Sophora subprostrata (Sang zhi huai) etc. were used as traditional herbal in Eastern Asian countries (He et al, 2015;Aly et al, 2019). According to the theory of traditional Chinese medicine (TCM), these natural products display various activities in "clearing heat", "dispelling dampness", "relieving pain and swelling" and "sedation and detoxification".…”

Section: Introductionmentioning

confidence: 99%

A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms

Zhou

Sun

et al. 2020

Front. Pharmacol.

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Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following the rationale of reductionism, subsequent biochemical analyses attribute such anti-dysentry effect to the bactericidal activity of aloperine. From then on, the multiple roles of aloperine are gradually revealed. Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. To facilitate further investigation, herein, we conclude the key pharmacological functions of aloperine, and most importantly, the underlying cellular and molecular mechanisms are clarified in detail to explain the functional mode of aloperine.

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The pharmacology of the genus Sophora (Fabaceae): An updated review

Cited by 46 publications

References 149 publications

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

Biological Activity of Naturally Derived Naphthyridines

A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms

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