The phenomenon of long-term survival in glioblastoma patients. Part I: the role of clinical and demographic factors and an IDH1 mutation (R 132 H)

Goryaynov, S A; Goldberg, Maria; Golanov, Andrey; Zolotova, S V; Shishkina, L V; Ryzhova, Marina; Pitskhelauri, D I; Zhukov, V Yu; Usachev, D Yu; Kondrashov, Alexander; Shurkhay, Vsevolod; Потапов, А А

doi:10.17116/neiro20178135-16

Cited by 9 publications

(2 citation statements)

References 43 publications

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“…Мутация гена IDH2 в глиомах Grade II-III встречается реже. В последние годы было показано, что мутации генов IDH1 и IDH2 являются прогностическими факторами замедленной прогрессии опухоли и увеличения общей выживаемости пациентов [53][54][55]. Мутационный статус IDH1 и IDH2 является на сегодняшний день одной из главных прогностических и диагностических характеристик астроцитом, широко используемой в новой классификации опухолей нервной системы ВОЗ [56].…”

Section: мутации Idh в клетках глиомunclassified

The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors

Никитин¹,

Потапов²,

Ryzhova³

et al. 2018

Vopr. neirokhir.

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The relationship between molecular genetic and metabolic disorders is one of the challenges of modern oncology. In this review, we consider lipid metabolism and its changes as one of the factors of oncogenesis of glial tumors. Also, we demonstrate that the genome and the metabolome are interconnected by a large number of links, and the metabolic pathways, during their reorganization, are able to drastically affect the genetic structure of the cell and, in particular, cause its tumor transformation. Our own observations and analysis of the literature data allow us to conclude that mass spectrometry is a highly accurate current method for assessing metabolic disorders at the cellular level. The use of mass spectrometry during surgery allows the neurosurgeon to obtain real-time data on the level of specific molecular markers in the resected tissue, thereby bringing intraoperative navigation techniques to the molecular level. The generation of molecular fingerprints for each tumor significantly complements the available neuroimaging, molecular genetic, and immunohistochemical data.

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Section: мутации Idh в клетках глиомunclassified

The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors

Никитин¹,

Потапов²,

Ryzhova³

et al. 2018

Vopr. neirokhir.

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“…Emerging evidence from various research groups suggests a positive association between IDH mutation status and improved clinical outcomes, particularly in terms of extended overall survival rates, for grade 4 astrocytoma patients [54,[56][57][58].…”

Section: Idh1 Idh2mentioning

confidence: 99%

Potential Diagnostic and Clinical Significance of Selected Genetic Alterations in Glioblastoma

Tomoszková,

Škarda,

Lipina

2024

IJMS

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Glioblastoma is currently considered the most common and, unfortunately, also the most aggressive primary brain tumor, with the highest morbidity and mortality rates. The average survival of patients diagnosed with glioblastoma is 14 months, and only 2% of patients survive 3 years after surgery. Based on our clinical experience and knowledge from extensive clinical studies, survival is mainly related to the molecular biological properties of glioblastoma, which are of interest to the general medical community. Our study examined a total of 71 retrospective studies published from 2016 through 2022 and available on PubMed that deal with mutations of selected genes in the pathophysiology of GBM. In conclusion, we can find other mutations within a given gene group that have different effects on the prognosis and quality of survival of a patient with glioblastoma. These mutations, together with the associated mutations of other genes, as well as intratumoral heterogeneity itself, offer enormous potential for further clinical research and possible application in therapeutic practice.

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Patients with Long-Term Survival in Malignant Gliomas after Photodynamic Therapy

Rynda,

Olyushin,

Rostovtsev

et al. 2024

Neurosci Behav Physi

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The phenomenon of long-term survival in glioblastoma patients. Part I: the role of clinical and demographic factors and an IDH1 mutation (R 132 H)

Cited by 9 publications

References 43 publications

The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors

The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors

Potential Diagnostic and Clinical Significance of Selected Genetic Alterations in Glioblastoma

Patients with Long-Term Survival in Malignant Gliomas after Photodynamic Therapy

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